Journal Article10.1016/S0531-5565(02)00130-4
Chronic in vivo exposure to glucocorticoids prolongs cellular lifespan: the case of Cushing's syndrome-patients' fibroblasts
Harris Pratsinis,Stylianos Tsagarakis,Irene Zervolea,Fivos Giannakopoulos,Dimitri Stathakos,N. Thalassinos,Dimitris Kletsas +6 more
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TL;DR: The hypothesis that stress response may have beneficial consequences in cellular longevity, as well as in tissue homeostasis is supported.
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About: This article is published in Experimental Gerontology. The article was published on 01 Oct 2002. The article focuses on the topics: Tissue homeostasis.
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Citations
Hormesis in aging.
TL;DR: Hormesis in aging is represented by mild stress-induced stimulation of protective mechanisms in cells and organisms resulting in biologically beneficial effects that counter-balances the progressive shrinkage of the homeodynamic space, which is the ultimate cause of aging, diseases and death.
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Antiproliferative Activity of Greek Propolis
TL;DR: The butanolic extract and the isolated chemical constituents, mainly diterpenes and flavonoids, from Greek propolis have been tested for their cytostatic activities against human malignant and normal cell strains, and manool was the most active compound.
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Hyperjovinols A and B: Two new phloroglucinol derivatives from Hypericum jovis with antioxidant activity in cell cultures.
Konstantinos Athanasas,Prokopios Magiatis,Nikolas Fokialakis,Alexios-Leandros Skaltsounis,Harris Pratsinis,Dimitris Kletsas +5 more
TL;DR: Two new and four known phloroglucinol derivatives were isolated from the dichloromethane extract of the Greek endemic plant Hypericum jovis and demonstrated significant antioxidant activity, while two of them possessed activity at a cellular level comparable to Trolox, protecting against ROS.
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The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing's syndrome.
Irene Zervolea,Harris Pratsinis,Stylianos Tsagarakis,Niki Karavitaki,Dimitri Stathakos,N. Thalassinos,Dimitris Kletsas +6 more
TL;DR: Functional characteristics of CFs are in contrast to the known catabolic effects of GCs, and suggest that prior exposure to GC excess is not associated with a persisting adverse outcome in the functional phenotype of the fibroblasts.
Hormesis and aging
Suresh I. S. Rattan,Dino Demirovic +1 more
- 01 Jan 2010
TL;DR: Healthy aging may be achieved through mild and periodic but not severe or chronic physical and mental challenges and by the use of nutritional hormesis incorporating mild stress-inducing molecules called hormetins.
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References
Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology
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Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions
TL;DR: It is proposed that stress-induced increases in glucocorticoid levels protect not against the source of stress itself but rather against the body's normal reactions to stress, preventing those reactions from overshooting and themselves threatening homeostasis.
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Cushing's Syndrome
TL;DR: Treatment for Cushing's syndrome should aim to cure the hypercortisolism and to eliminate any tumor that threatens the patient's health, while minimizing the chance of an endocrine deficiency or long-term dependence on medications.
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