Chronic bladder ischemia and oxidative stress: New pharmacotherapeutic targets for lower urinary tract symptoms
TL;DR: Improvement of lower urinary tract perfusion and control of oxidative stress can be considered new therapeutic strategies for treatment of bladder dysfunction induced by chronic ischemia.
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Abstract: Chronic bladder ischemia is potentially a common cause of lower urinary tract symptoms in the elderly. Epidemiological studies have shown a close association between lower urinary tract symptoms and vascular risk factors for atherosclerosis, and investigations using transrectal color Doppler ultrasonography have shown a negative correlation between decreased lower urinary tract perfusion and International Prostate Symptom Score in elderly patients with lower urinary tract symptoms. Bladder blood flow is also known to decrease in men with bladder outlet obstruction as a result of benign prostatic hyperplasia. Studies in animal models suggest that chronic bladder ischemia and repeated ischemia/reperfusion during a micturition cycle might produce oxidative stress, leading to denervation of the bladder and the expression of tissue-damaging molecules in the bladder wall, which could be responsible for the development of bladder hyperactivity progressing to bladder underactivity. The effects of drugs with different mechanisms of action; for example, α1-adrenoceptor antagonists, phosphodiesterase type 5 inhibitors, free radical scavengers and β3-adrenoceptor agonist, have been studied in animal models of chronic bladder ischemia. The drugs, representing different treatment principles for increasing blood flow and decreasing oxidative stress, showed protective effects not only on urodynamic parameters, but also on negative effects on muscle contractility and on detrimental structural bladder wall changes. Improvement of lower urinary tract perfusion and control of oxidative stress can be considered new therapeutic strategies for treatment of bladder dysfunction induced by chronic ischemia.
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Citations
Chronic ethanol consumption induces micturition dysfunction and alters the oxidative state of the urinary bladder
Gabriel T. do Vale,Arthur H. Sousa,Natália A. Gonzaga,Mariana G. de Oliveira,Alberto Fernando Oliveira Justo,Eduardo C. Alexandre,Jose E. Tanus-Santos,Edson Antunes,Carlos R. Tirapelli +8 more
- 01 Jan 2019
TL;DR: In this paper, the authors evaluated whether ethanol consumption would increase oxidative stress and found that it was a major mechanism by which ethanol induces functional and structural changes in distinctive tissues.
1
A Role For Transforming Growth Factor-Beta In Urinary Bladder Dysfunction With Cyclophosphamide-Induced Cystitis
Eric J. Gonzalez
- 01 Jan 2016
TL;DR: A causal link is established between an inflammatory mediator, TGF-β, and intrinsic signaling mechanisms of the urothelium that may contribute to the altered sensory processing of bladder filling to facilitate increased voiding frequency and have the potential to improve the health of those suffering from inflammation-associated bladder syndromes.
Oxidative stress is associated with bladder dysfunction: An issue of functional urology deserving an in-depth study
TL;DR: In my opinion, the authors have contributed to unveiling a part of the features of KIC, and provided clues for in-depth studies of the mechanism of action of green tea catechins.
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References
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
21.2K
Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Countries: Results of the EPIC Study
Debra E. Irwin,Ian Milsom,Steinar Hunskaar,Kate Reilly,Zoe Kopp,Sender Herschorn,Karin S. Coyne,Con Kelleher,Christian Hampel,Walter Artibani,Paul Abrams +10 more
TL;DR: The EPIC study is the largest population-based survey to assess prevalence rates of OAB, UI, and other LUTS in five countries and is the first study to evaluate these symptoms simultaneously using the 2002 ICS definitions.
2.6K
Antiinflammatory Properties of HDL
Philip J. Barter,Stephen J. Nicholls,Kerry-Anne Rye,Gattadahalli M. Anantharamaiah,Mohamad Navab,Alan M. Fogelman +5 more
TL;DR: In this paper, HDL has been shown to have anti-atherogenic properties, which may explain the ability of HDL to promote the efflux of cholesterol from cells in the artery wall.
The free radical theory of aging.
TL;DR: The free radical theory of aging postulates that aging changes are caused by free radical reactions, and data indicate that average life expectancy at birth may be increased by 5 or more years, by nutritious low caloric diets supplemented with one or more free radical reaction inhibitors.
1.2K