Journal Article10.1016/S0165-4608(01)00395-8
Chromosomal aberrations in malignant gastrointestinal stromal tumors: correlation with c-KIT gene mutation.
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TL;DR: In this article, the authors looked for recurrent numerical chromosomal changes, which may be associated with malignant GISTs, using interphase fluorescence in situ hybridization (FISH).
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About: This article is published in Cancer Genetics and Cytogenetics. The article was published on 01 Jul 2001. The article focuses on the topics: Chromosome 7 (human) & Chromosome 9.
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Citations
Assessing the Prognosis of Gastrointestinal Stromal Tumors A Growing Role for Molecular Testing
TL;DR: This important study, the first in the post-KIT era, confirms 2 general observations about GISTs: (1) the great majority of very-low-risk, low- risk, and intermediate-risk Gists behave in a benign manner, and (2) among these tumors, there is an unpredictable subset that behaves aggressively.
Chromosomal Numerical Abnormality Profiles of Gastrointestinal Stromal Tumors
Kimihiro Yamashita,Hisaki Igarashi,Yasuhiko Kitayama,Takachika Ozawa,Shinichiro Kiyose,Hiroyuki Konno,Teruhisa Kazui,Shumpei Ishikawa,Hiroyuki Aburatani,Fumihiko Tanioka,Masaya Suzuki,Haruhiko Sugimura +11 more
TL;DR: The extent of CNA differed between GISTS with and without recurrence or metastasis; thus, FISH analysis of specimens from the primary sites may predict the biological behavior of this tumor.
Clinicopathologic factors and nuclear morphometry as independent prognosticators in KIT-positive gastrointestinal stromal tumors.
Sonja E. Steigen,Bjørn Straume,Dmitry Turbin,Andy K. W. Chan,Samuel Leung,Torsten O. Nielsen,Sigurd Lindal +6 more
TL;DR: Morphometric variables in 422 GISTs were significant for overall survival in univariate analyses but did not retain independent significance in multivariate analyses incorporating mitotic count and tumor size.
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Primary Extragastrointestinal Stromal Tumours in the Hepatobiliary Tree and Telocytes
Somanath Padhi,Hemanta K. Nayak +1 more
TL;DR: There seems to be a direct link between these enigmatic stromal cells and pathogenesis of gallstones and origin of EGISTs, and a hope for targeted therapies and the possible role of telocytes in hepatic regeneration and liver fibrosis opens a new dimension for futuristic research.
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The cyclin-dependent kinase inhibitor, p27, has no correlation with the malignant potential of GIST.
Haim Shirin,Vladimir Kravtsov,Mark Shahmurov,Vered Sehayek Shabat,Ivgeni Krinshpon,Avi Alin,Ilana Avinoach,Yona Avni +7 more
TL;DR: The cyclin-dependent kinase inhibitor p27kip1 was not associated with malignancy of GISTs and did not serve as a predictor of survival.
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References
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Seiichi Hirota,Koji Isozaki,Yasuhiro Moriyama,Koji Hashimoto,Toshirou Nishida,Shingo Ishiguro,Kiyoshi Kawano,Masato Hanada,Akihiko Kurata,Masashi Takeda,Ghulam Muhammad Tunio,Yuji Matsuzawa,Yuzuru Kanakura,Yasuhisa Shinomura,Yukihiko Kitamura +14 more
TL;DR: Sequencing of c-kit complementary DNA from five GISTs revealed mutations in the region between the transmembrane and tyrosine kinase domains, suggesting that the mutations contribute to tumor development.
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Gastrointestinal stromal tumors: recent advances in understanding of their biology.
Markku Miettinen,Markku Miettinen,Maarit Sarlomo-Rikala,Maarit Sarlomo-Rikala,Jerzy Lasota,Jerzy Lasota +5 more
TL;DR: The cell of origin is not fully understood, but resemblance to the interstitial cells of Cajal, expression of some smooth muscle markers, and occurrence outside of the GI-tract suggest origin from multipotential cells that can differentiate into Cjal and smooth muscle cells.
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•Dissertation
Effect of c-kit Mutation on Prognosis of Gastrointestinal Stromal Tumors
正彦 谷口
- 08 Aug 2001
•Journal Article
DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance.
TL;DR: The results show that several DNA copy number changes are related to the behavior of GISTs and can be used as prognostic markers for tumor progression.
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Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors.
Christopher A. Moskaluk,Qingsheng Tian,C R Marshall,Craig A. Rumpel,D W Franquemont,Henry F. Frierson +5 more
TL;DR: It is concluded that mutation of the c-kit JM domain does not occur in gastrointestinal mesenchymal neoplasms with well developed-smooth muscle differentiation, and is restricted to GISTs.
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