Journal Article10.1182/BLOOD-2002-09-2767
Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBPα and C/EBPε) and CDP/cut in myeloid maturation-induced lactoferrin gene expression
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TL;DR: It is concluded that C/EBPα, C/EBPe, and CDP/cut all play definitive roles in regulating late gene expression during normal myeloid development.
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About: This article is published in Blood. The article was published on 01 May 2003. The article focuses on the topics: Ccaat-enhancer-binding proteins & Chromatin immunoprecipitation.
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References
Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.
TL;DR: The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and “cut repeats”, predicting a broad role for CDP in mammalian development.
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CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment.
Dorothy J. Park,A.M. Chumakov,Peter T. Vuong,D.Y. Chih,Adrian F. Gombart,W.H. Miller,H P Koeffler +6 more
TL;DR: The data strongly suggest that C/EBPepsilon is a downstream target gene responsible for RA-induced granulocytic differentiation of APL cells.
202
Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein ε
TL;DR: The multiple functional defects observed in these early neutrophil progenitor cells, a consequence of C/EBPε deficiency, define SGD as a defect in myelopoiesis and establish the requirement for C/ EBPε for the promyelocyte–myelocyte transition in myELoid differentiation.
Coexamination of Site-Specific Transcription Factor Binding and Promoter Activity in Living Cells
Kathryn E. Boyd,Peggy J. Farnham +1 more
TL;DR: It is shown that both Myc and USF bind to the exact same E box on the cad promoter, suggesting that competition between these two factors for a single site occurs in living cells and that cell cycle-regulated transcriptional activation of the cadpromoter may be a stochastic, rather than a predetermined, process.
184
Transformation of sensory organ identity by ectopic expression of Cut in Drosophila.
TL;DR: It is demonstrated that ubiquitous Cut expression in embryos results specifically in the morphologic and antigenic transformation of ch organs into es organs, and that Cut is not only necessary but sufficient for the specification of es organ identify in sensory organ precursor cells and their progeny.