Journal Article10.1016/j.carbpol.2023.121395
Chitosan-based Schiff bases: Promising materials for biomedical and industrial applications
Varun Pawariya,Soumik De,Joydeep Dutta +2 more
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TL;DR: This review article, an attempt has been exclusively made to demonstrate the syntheses of various chitosan-based Schiff bases (CSBs) simply by allowing the reactions of reactive amino groups of chitOSan with different aldehydes/ketones of interest.
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Abstract: There is plenty of scope for modifying chitosan, an only polycationic natural polysaccharide, owing to its reactive functional groups, namely hydroxyl and amino groups. Although innumerable numbers of chitosan derivatives have been synthesized by modifying these groups and reported elsewhere, in this review article, an attempt has been exclusively made to demonstrate the syntheses of various chitosan-based Schiff bases (CSBs) simply by allowing the reactions of reactive amino groups of chitosan with different aldehydes/ketones of interest. Due to their very peculiar and unique characteristics, such as biodegradability, biocompatibility, metal-binding capability, etc., they are found to be very useful for diversified applications. Thus, we have also attempted to showcase their very specific biomedical fields, including tissue engineering, drug delivery, and wound healing, to name a few. In addition, we have also discussed the utilization of CSBs for industrial applications such as wastewater treatment, catalysis, corrosion inhibition, sensors, etc.
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TL;DR: This review synthesizes the antioxidant potential of Schiff base ligands, highlighting their structure, solvent effects, and electron-donating groups' role in radical stabilization, suggesting their eco-friendly antioxidant properties via the DPPH scavenging assay.
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Varun Pawariya,Soumik De,Joydeep Dutta +2 more
TL;DR: A citric acid-modified chitosan Schiff base was synthesized, exhibiting enhanced antibacterial properties and efficient dye removal (348 mg.g−1 for BBR, 145 mg.g−1 for RhB) from wastewater, with Langmuir and Freundlich isotherm model consistency.
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Antibacterial and Antifungal Pyrazoles Based on Different Construction Strategies
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Abstract: The growing prevalence of microbial infections, and antimicrobial resistance (AMR) stemming from the overuse and misuse of antibiotics, call for novel therapeutic agents, particularly ones targeting resistant microbial strains. Scientists are striving to develop innovative agents to tackle the rising microbial infections and abate the risk of AMR. Pyrazole, a five-membered heterocyclic compound belonging to the azole family, is a versatile scaffold and serves as a core structure in many drugs with antimicrobial and other therapeutic effects. In this review, we have updated pyrazole-based antibacterial and antifungal agents mainly developed between 2016 and 2024, by combining with diverse pharmacophores such as coumarin, thiazole, oxadiazole, isoxazole, indole, etc. Meanwhile, the various strategies (molecular hybridization, bioisosterism, scaffold hopping, multicomponent reactions, and catalyst-free synthesis) for integrating different functional groups with the pyrazole ring are discussed. Additionally, structure-activity relationships of these pyrazole derivatives, i.e., how structural modifications impact their selectivity and therapeutic potential against bacterial and fungal strains, are highlighted. This review provides insights into designing next-generation antimicrobials to combat AMR, and offers valuable perspectives to the scientists working on heterocyclic compounds with diverse bioactivities.
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Nanocomposites against Pseudomonas aeruginosa biofilms: Recent advances, challenges, and future prospects.
Basma A. Omran,Boo Shan Tseng,Kwang-Hyun Baek +2 more
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References
Novel heterocyclic chitosan‐based Schiff base: evaluation as adsorbent for removal of methyl orange from aqueous solution
A.S. Manchaiah,V. Badalamoole +1 more
Abstract: A Schiff base has been made by reacting chitosan with 2‐hydroxy quinoline‐3‐carbaldehyde in the presence of acetic acid. The synthesized compound was characterized by FTIR, TGA, XRD and SEM techniques. The Schiff base was evaluated for removal of anionic dye from aqueous solution using methyl orange as model dye. Influences of initial dye concentration, pH and contact time on the extent of adsorption were investigated. The adsorption data fits best with Freundlich isotherm model and the maximum adsorption capacity was found to be 55.55 mg/g. The kinetic study indicated second‐order adsorption. The thermodynamic parameters showed the adsorption to be endothermic and non‐spontaneous. Desorption studies indicated the reusability of the compound as adsorbent material.
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Synthesis and characterization of chitosan-pyrazoloquinoxaline Schiff bases for Cr (VI) removal from wastewater.
TL;DR: Both chitosan Schiff bases showed high removal efficiency, the result indicated that Cr (VI) removal using Ch-PQ1 and Ch- PQ2 was 96.4% and 98.8% respectively.
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Synthesis, and characterization of chitosan bearing pyranoquinolinone moiety for textile dye adsorption from wastewater
TL;DR: Chitosan Schiff base resulted in 100% removal of carcinogenic dye at 2 min only with qm 344.8 mg/g, and may do the same for other anionic reactive dyes, thus avoiding secondary pollution.
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Synthesis and characterization of a new developed modified-chitosan Schiff base with improved antibacterial properties for the removal of Bismarck Brown R and Eosin Y dyes from wastewater
Varun Pawariya,Soumik De,Joydeep Dutta +2 more
TL;DR: A new modified-chitosan Schiff base with improved antibacterial properties was synthesized and characterized, demonstrating high adsorption efficacy for Bismarck Brown R (327 mg/g) and Eosin Y (386 mg/g) dyes, and effective removal from wastewater.
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Surface functionalization of chitosan with 5-nitroisatin.
TL;DR: It was determined that the covalent functionalization through Schiff base formation is possible and a new Schiff base from condensation reaction of CS and NI (CSB) together with its Ni(II) and Cu( II) complexes was synthesized.
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