Chinese drugs of plant origin
Weici Tang,Gerhard Eisenbrand +1 more
- 02 Dec 1992
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About: The article was published on 02 Dec 1992.
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Applications and opportunities for ultrasound assisted extraction in the food industry-a review
TL;DR: In this paper, the use of ultrasonic assisted extraction (UAE) for food and allied industries is discussed, including the potential for modification of plant cell material to provide improved bioavailability of micro-nutrients while retaining the natural-like quality.
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GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
Laurent Meijer,Alexios-Leandros Skaltsounis,Prokopios Magiatis,Panagiotis Polychronopoulos,Marie Knockaert,Maryse Leost,Xiaozhou P. Ryan,Claudia Alin Vonica,Ali H. Brivanlou,Rana Dajani,Claudia Crovace,Cataldo Tarricone,Andrea Musacchio,S. Mark Roe,Laurence H. Pearl,Paul Greengard +15 more
TL;DR: 6-bromoindirubins provide a new scaffold for the development of selective and potent pharmacological inhibitors of GSK-3, and closely mimicked Wnt signaling in Xenopus embryos.
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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
Ralph Hoessel,Sophie Leclerc,Jane A. Endicott,Martin E. M. Nobel,Alison M. Lawrie,Paul Tunnah,Maryse Leost,Eve Damiens,Dominique Marie,Doris Marko,Ellen Niederberger,Weici Tang,Gerhard Eisenbrand,Laurent Meijer +13 more
TL;DR: Indirubin-3′-monoxime inhibits the proliferation of a large range of cells, mainly through arresting the cells in the G2/M phase of the cell cycle, which has implications for therapeutic optimization of indigoids.
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Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease A PROPERTY COMMON TO MOST CYCLIN-DEPENDENT KINASE INHIBITORS?
Sophie Leclerc,Matthieu Garnier,Ralph Hoessel,Doris Marko,James A. Bibb,Gretchen L. Snyder,Paul Greengard,Jacek Biernat,Yong-Zhong Wu,Eva-Maria Mandelkow,Gerhard Eisenbrand,Laurent Meijer +11 more
TL;DR: It is reported here that indirubins are also powerful inhibitors (IC(50): 5-50 nm) of an evolutionarily related kinase, glycogen synthase kinase-3beta (GSK-3 beta), and it is shown that many, but not all, reported CDK inhibitors are powerful inhibitors of GSK-3 Beta.
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The chemistry of recently isolated naturally occurring quinazolinone alkaloids
TL;DR: A concise account of the isolation, bioactivity, and synthesis of bioactive quinazolinone-based natural products for the period 1983-2005 is given in this paper.
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References
Potential anticancer activity of turmeric (Curcuma longa)
TL;DR: Initial experiments indicated that turmeric extract and curcumin reduced the development of animal tumours.
708
A study on the fate of curcumin in the rat
Bo Wahlström,G. Blennow +1 more
TL;DR: It is unlikely that substantial concentrations of curcumin occur in the body after ingestion, as measured of blood plasma levels and biliary excretion showed that curcuron was poorly absorbed from the gut.
651
Absorption and tissue distribution of curcumin in rats
TL;DR: The urinary excretion of conjugated glucuronides and sulfates significantly increased and the concentration of curcumin remaining in the lower part of the gut namely caecum and large intestine amounted to 38% of the quantity administered.
466
Berberine sulfate: antimicrobial activity, bioassay, and mode of action.
TL;DR: Berberine sulfate was shown to possess antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.
301
Metabolism of curcumin - studies with [-3H]curcumin.
TL;DR: Radioactivity was detectable in blood, liver and kidney following dosage with 400, 80 or 10 mg of [3H]curcumin; the major route of elimination of the label was the feces; the urinary excretion was very low regardless of the dose.
265
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