CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease
Miaomiao Jia,Xueqin Zou,Shuying Yin,Weihong Tian,Yangjing Zhao,Hui Wang,Guoying Xu,Weili Cai,Qixiang Shao +8 more
TL;DR: Details of CHD4 in lymphocyte differentiation and development, as well as the critical role of CHd4 in the pathogenesis of the autoimmune disease are discussed.
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Abstract: Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the nucleosome remodeling and deacetylation complex. It has been implicated in gene transcription, DNA damage repair, maintenance of genome stability, and chromatin assembly. Meanwhile, it is highly related to cell cycle progression and the proceeding of malignancy. Most of the previous studies were focused on the function of CHD4 with tumor cells, cancer stem cells, and cancer cells multidrug resistance. Recently, some researchers have explored the CHD4 functions on the development and differentiation of adaptive immune cells, such as T and B lymphocytes. In this review, we will discuss details of CHD4 in lymphocyte differentiation and development, as well as the critical role of CHD4 in the pathogenesis of the autoimmune disease.
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CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease
Miaomiao Jia,Xueqin Zou,Shuying Yin,Weihong Tian,Yangjing Zhao,Hui Wang,Guoying Xu,Weili Cai,Qixiang Shao +8 more
TL;DR: Details of CHD4 in lymphocyte differentiation and development, as well as the critical role of CHd4 in the pathogenesis of the autoimmune disease are discussed.
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The Roles of H3K9me3 Writers, Readers, and Erasers in Cancer Immunotherapy
Urszula Oleksiewicz,Monika Kuciak,Anna Jaworska,Dominika Adamczak,Anna Bisok,Julia Mierzejewska,Justyna Sadowska,Patrycja Czerwińska,Andrzej Maćkiewicz +8 more
TL;DR: This review synthesizes existing literature on the roles of H3K9me3 writers, readers, and erasers in modulating cancer immunotherapy effectiveness, highlighting their pivotal influence on immune signaling and treatment outcomes.
2
Generation of a Well-Characterized Homozygous Chromodomain-Helicase-DNA-Binding Protein 4G1003D Mutant hESC Line Using CRISPR/eCas9 (ULIEGEe001-A-1)
TL;DR: In this article , a homozygous CHD4G1003D hESC line (WAe025-A-1) was generated using CRISPR/eCas9-based gene editing.
CHD4 Inhibits Lung Adenocarcinoma Cell Apoptosis and Induces Proliferation Via Upregulating PHF6
Ling Lin,Youwen Xu,Hongfei Ge,Susu He,Peng Wang +4 more
TL;DR: CHD4 promotes lung adenocarcinoma cell proliferation and inhibits apoptosis by upregulating PHF6, a process that is associated with increased expression of CHD4 and PHF6 in lung cancer tissues compared to normal tissues.
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