Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).
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TL;DR: The putative proteins encoded by CYP11B1 and B2 each contain 503 amino acids including a 24-residue signal peptide and have sequences that are 93% identical to each other and 75% identicalto the predicted sequence of bovine P-450(11) beta.
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About: This article is published in Journal of Biological Chemistry. The article was published on 15 Dec 1989. and is currently open access. The article focuses on the topics: Exon & Gene family.
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Citations
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•Dissertation
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- 02 Nov 2009
TL;DR: L’analyse plus approfondie d’une quinzaine de mutations rares a confirme l’existence of bonnes correlations phenotype-genotype comme ceci est decrit dans cette pathologie.
Emerging Trends in Small Molecule Inhibitors Targeting Aldosterone Synthase: A New Paradigm in Cardiovascular Disease Treatment
Guang-yun Zhang,Chengyong Wu,Yi Lei,Yuxi Wang,Jinliang Yang +4 more
- 01 May 2024
TL;DR: Recent research on small-molecule inhibitors targeting aldosterone synthase (CYP11B2) shows promise in treating hypertension, heart failure, and cardiometabolic diseases, but developing selective inhibitors remains a challenge due to high homology with CYP11B1.
2
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HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation.
TL;DR: The molecular genetic basis of congenital adrenal hyperplasia due to 21-Hydroxylase (21-OHase) deficiency is determined and it is hypothesized that the HLA-linked defect involved a structural gene for the adrenal microsomal cytochrome P-450 specific for steroid 21-hydroxylation.
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Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11)
Streamson C. Chua,Paul Szabo,Alena Vitek,Karl-Heinz Grzeschik,Maliyakal John,Perrin C. White +5 more
TL;DR: Combined cDNA and RNA sequence data demonstrated a continuous open reading frame of 1509 bases, useful in developing reagents for heterozygote detection and prenatal diagnosis of 11 beta-hydroxylase deficiency, the second most frequent cause of congenital adrenal hyperplasia.
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Gene Structure of Human Cytochrome P-450(SCC), Cholesterol Desmolase
TL;DR: A putative extension peptide consisting of 39 amino acids was found in the sequence of human P-450(SCC) by comparison with that of the bovine counterpart, suggesting a functional role of the portions in the mitochondrial localization and processing of P- 450(S CC) precursor.
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Purification and immunochemical characterization of the two adrenal cortex mitochondrial cytochrome P-450-proteins
TL;DR: The observed patterns of immunoprecipitation and inhibition of catalytic activity indicated that the two P -450 proteins are immunochemically different from each other.
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