Journal Article10.1021/JF404539Y
Characterization of antidiabetic and antihypertensive properties of canary seed (Phalaris canariensis L.) peptides.
Patricia A Estrada-Salas,Gabriela M. Montero-Morán,Pedro Pablo Martinez-Cuevas,Carmen G. Gonzalez,Ana P. Barba de la Rosa +4 more
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TL;DR: Results show that encrypted peptides in canary seed have inhibitory activity against DPPIV and ACE, enzymes that are targets for diabetes and hypertension treatments.
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Abstract: Canary grass is used as traditional food for diabetes and hypertension treatment. The aim of this work is to characterize the biological activity of encrypted peptides released after gastrointestinal digestion of canary seed proteins. Canary peptides showed 43.5% inhibition of dipeptidyl peptidase IV (DPPIV) and 73.5% inhibition of angiotensin-converting enzyme (ACE) activity. An isolated perfused rat heart system was used to evaluate the canary seed vasoactive effect. Nitric oxide (NO), a major vasodilator agent, was evaluated in the venous effluent from isolated perfused rat heart. Canary seed peptides (1 μg/mL) were able to induce the production of NO (12.24 μM) in amounts similar to those induced by captopril (CPT) and bradykinin (BK). These results show that encrypted peptides in canary seed have inhibitory activity against DPPIV and ACE, enzymes that are targets for diabetes and hypertension treatments.
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Citations
Food protein-derived bioactive peptides in management of type 2 diabetes
TL;DR: An overview of food protein-derived peptides as potential inhibitors of alpha-glucosidase and DPP-IV with major focus on milk proteins and the potential value of these peptides in the treatment and prevention of T2D is provided.
203
Peptides: Production, bioactivity, functionality, and applications
Mona Hajfathalian,Sakhi Ghelichi,Pedro J. García-Moreno,Ann-Dorit Moltke Sørensen,Charlotte Jacobsen +4 more
TL;DR: Production methods of hydrolysates and peptides are introduced and a comprehensive overview of their bioactivity in terms of their effects on immune, cardiovascular, nervous, and gastrointestinal systems is provided.
157
Structural and Antihypertensive Properties of Enzymatic Hemp Seed Protein Hydrolysates
TL;DR: It is concluded that an optimized combination of the fast-acting HPH (1% alcalase) with the longer-lasting HPHs (2% and 4% pepsin) could provide daily effective SBP reductions.
Structure and function of plant protein-derived antihypertensive peptides
TL;DR: The structural basis for enhanced peptide activity varies but generally peptides that contain proline, branched-chain amino acids and aromatic amino acids have strong inhibitory activities against renin and ACE.
109
Inhibitory activity of chia (Salvia hispanica L.) protein fractions against angiotensin I-converting enzyme and antioxidant capacity
TL;DR: In this paper, the authors identify the chia protein fractions and determine their anti-hypertensive potential and their antioxidant and ion chelating capacity, and demonstrate that chia can be considered a seed with antioxidative potential and as a novel anti-hyperpertensive source; important factors for the frequent incorporation of chia in the human diet.
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Antihypertensive peptides and γ-aminobutyric acid from prozyme 6 facilitated lactic acid bacteria fermentation of soymilk
TL;DR: In this paper, the soymilk was fermented with five lactic acid bacteria for up to 30h at 42°C and a protease, prozyme 6, was added 5h after fermentation.