Characterization and propagation of uncertainty in diffusion-weighted MR imaging.
Timothy E.J. Behrens,Mark W. Woolrich,Mi Jenkinson,Heidi Johansen-Berg,Rita G. Nunes,Stuart Clare,Paul M. Matthews,J M Brady,Stephen M. Smith +8 more
TL;DR: A fully probabilistic framework is presented for estimating local probability density functions on parameters of interest in a model of diffusion, allowing for the quantification of belief in tractography results and the estimation of the cortical connectivity of the human thalamus.
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Abstract: A fully probabilistic framework is presented for estimating local probability density functions on parameters of interest in a model of diffusion. This technique is applied to the estimation of parameters in the diffusion tensor model, and also to a simple partial volume model of diffusion. In both cases the parameters of interest include parameters defining local fiber direction. A technique is then presented for using these density functions to estimate global connectivity (i.e., the probability of the existence of a connection through the data field, between any two distant points), allowing for the quantification of belief in tractography results. This technique is then applied to the estimation of the cortical connectivity of the human thalamus. The resulting connectivity distributions correspond well with predictions from invasive tracer methods in nonhuman primate.
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Citations
Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants
Stuart J. Ritchie,Simon R. Cox,Xueyi Shen,Michael V. Lombardo,Michael V. Lombardo,Lianne M. Reus,Clara Alloza,Mathew A. Harris,Helen L Alderson,Stuart Hunter,Emma Neilson,David C. Liewald,Bonnie Auyeung,Heather C. Whalley,Stephen M. Lawrie,Catharine R. Gale,Catharine R. Gale,Mark E. Bastin,Andrew M. McIntosh,Ian J. Deary +19 more
TL;DR: This large-scale study provides a foundation for attempts to understand the causes and consequences of sex differences in adult brain structure and function.
Orientationally invariant indices of axon diameter and density from diffusion MRI
Daniel C. Alexander,Penny L. Hubbard,Matthew Hall,Elizabeth A. Moore,Maurice Ptito,Geoffrey J. M. Parker,Tim B. Dyrby +6 more
TL;DR: Maps of axon diameter and density indices from the monkey and human data in the corpus callosum and corticospinal tract reflect known trends from histology.
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Deterministic and Probabilistic Tractography Based on Complex Fibre Orientation Distributions
TL;DR: An integral concept for tractography to describe crossing and splitting fibre bundles based on the fibre orientation distribution function (ODF) estimated from high angular resolution diffusion imaging (HARDI) is proposed and new deterministic and new probabilistic tractography algorithms using the full multidirectional information obtained through use of the fibre ODF are developed.
White matter damage and cognitive impairment after traumatic brain injury.
Kirsi M. Kinnunen,Richard Greenwood,Jane H. Powell,Robert Leech,Peter C.T. Hawkins,Valerie Bonnelle,Maneesh C. Patel,Serena J. Counsell,David J. Sharp +8 more
TL;DR: A stratified analysis based on the presence or absence of microbleeds revealed diffusion tensor imaging to be more sensitive than gradient-echo imaging to white matter damage and the location of white matter abnormality predicted cognitive function to some extent.
Graph theoretical modeling of brain connectivity.
Yong He,Alan C. Evans +1 more
TL;DR: This review will focus mainly on recent findings concerning graph theoretical analysis of human brain networks with a variety of imaging modalities, exploring whether graph-based brain network analysis could yield reliable biomarkers for disease diagnosis and treatment.
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