Book Chapter10.1016/B978-1-4160-3160-4.10004-5
Chapter 4 – Innate Immunity and Epithelial Biology: Special Considerations in the Neonatal Gut
Patricia W. Lin,Andrew S. Neish +1 more
- 01 Jan 2008
- pp 51-72
4
About: The article was published on 01 Jan 2008. The article focuses on the topics: Innate immune system.
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Citations
Pathogenesis of NEC: Role of the innate and adaptive immune response
TL;DR: The role of the innate and adaptive immune system in the pathophysiology of NEC is reviewed and an abnormal bacterial colonization pattern with a deficiency of commensal bacteria may lead to a further breakdown of host defense mechanisms.
97
Developmental biology of gut-probiotic interaction
TL;DR: Improved knowledge of gut-probiotic interaction in developing epithelia will allow for a better understanding of how probiotics exert their beneficial effects and help guide their therapeutic use.
59
The Intestinal Immune Barrier
Nancy A. Louis,Patricia W. Lin +1 more
TL;DR: The developing neonatal gut faces an additional daunting challenge of successfully negotiating the transition from a sterile lumen devoid of digestive and microbial metabolic products to the fully realized “bioreactor” of the adult gut.
18
Heat shock pretreatment reduces intestinal injury in a neonatal rat model of early necrotizing enterocolitis.
Ee Kyung Kim,Kyeung Yeup Lee,Hyun Ju Lee,Jin A Lee,Chang Won Choi,Han Suk Kim,Beyong Il Kim,Jung Hwan Choi +7 more
TL;DR: Whether heat shock pretreatment protects intestinal epithelial damage in the early NEC rat model is investigated and it is suggested that inhibition of NF-ĸB activation through increased HSP70 expression is a possible mechanism underlying this protective effect.
10
References
MAP kinase signalling cascade in Arabidopsis innate immunity
Tsuneaki Asai,Guillaume Tena,Joulia Plotnikova,Matthew R. Willmann,Wan-Ling Chiu,Lourdes Gómez-Gómez,Thomas Boller,Frederick M. Ausubel,Jen Sheen +8 more
TL;DR: An Arabidopsis thaliana leaf cell system based on the induction of early-defence gene transcription by flagellin, a highly conserved component of bacterial flagella that functions as a PAMP in plants and mammals is developed, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade.
2.7K
NF-κB at the crossroads of life and death
Michael Karin,Anning Lin +1 more
TL;DR: The choice between life and death is one of the major events in regulation of the immune system and a major regulator of such life or death decisions is the transcription factor NF-κB as mentioned in this paper.
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Katherine A. Fitzgerald,Sarah M. McWhirter,Kerrie L. Faia,Daniel C. Rowe,Eicke Latz,Douglas T. Golenbock,Anthony J. Coyle,Sha-Mei Liao,Tom Maniatis +8 more
TL;DR: It is reported that the noncanonical IκB kinase homologs, IKKε (IKKε) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-κB activation, are also essential components of the IRF3 signaling pathway.
2.6K
Commensal Host-Bacterial Relationships in the Gut
Lora V. Hooper,Jeffrey I. Gordon +1 more
TL;DR: The current genomic revolution offers an unprecedented opportunity to identify the molecular foundations of symbionts and commensals so that the authors can understand how they contribute to their normal physiology and how they can be exploited to develop new therapeutic strategies.
2.5K
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
TL;DR: Coloring germ-free mice with Bacteroides thetaiotaomicron reveals that this commensal bacterium modulates expression of genes involved in several important intestinal functions, including nutrient absorption, mucosal barrier fortification, xenobiotic metabolism, angiogenesis, and postnatal intestinal maturation.
2.3K
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