Book Chapter10.1016/B978-0-12-374530-9.00012-7
Chapter 10 – Lymphocyte Trafficking
Avi N Kogan,Ulrich H. von Andrian +1 more
- 01 Jan 2008
pp 449-482
9
TL;DR: This chapter focuses on the various elements and principles involved in lymphocyte trafficking.
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Abstract: Publisher Summary
This chapter focuses on the various elements and principles involved in lymphocyte trafficking. Lymphocytes are the cornerstone of the adaptive immune response and the basis of immunological memory. In order to protect the body, lymphocytes must be able to access the many sites where pathogens may appear. Toward this end they continually travel through the body by way of the circulatory and lymphatic systems. The circulatory system provides rapid access to bodily tissues, but is more than a mere highway along which lymphocytes travel. The lymphatic system, which ultimately channels lymph back into the circulation via the thoracic duct, provides a route for lymphocytes that have exited the bloodstream to return and circulate anew. Antigen-inexperienced lymphocytes patrolling for foreign substances can thus continuously migrate from blood to secondary lymphoid organ (SLO) to lymph and back to blood again. By the same token, antigen-experienced effector lymphocytes can reach infected tissues to help neutralize and eliminate the pathogen(s), while memory cells can return to previously infected sites to guard against pathogen reappearance. Primary lymphoid organs include thymus, and bone marrow. SLO include peripheral lymph nodes, peye's patches, mesenteric lymph nodes, and spleen.
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