Changes in plasma protein binding have little clinical relevance.

TL;DR: The role of efflux transporters in TB drug handling is reviewed, the promise ofefflux pump inhibition from a novel holistic perspective is evaluated, and the emergence of phenotypic tolerance and drug resistance is evaluated.

TL;DR: Whether as an industry the authors have become overly focused on properties or metrics that are within their understanding and control, even though they know they are of finite relevance, is discussed.

TL;DR: PPB is an effective parameter for defining clearance rate determination for acidic and zwitterionic drugs with high MWs and is used as an additional parameter in ECCS, clearance mechanisms for class 1B and 3B compounds can be predicted, and OATP and Oat substrates may be readily distinguished.

TL;DR: The case of an unpredictable lack of interaction between CsA and telaprevir in a liver transplant recipient and the mechanism leading to this lack of drug interaction in this patient has not been fully elucidated yet is likely to affect the absorption phase.

TL;DR: Basic clinical pharmacokinetics /, Basic clinical Pharmacokinetics , کتابخانه دیجیتال جندی شاپور اهواز

TL;DR: The administration of the pyrazolone derivatives, phenylbutazone and oxyphen butazone, to a patient already being treated with coumarin anticoagulant drugs can lead to serious hemorrhagic complications.