Journal Article10.1176/APPI.AJP.157.12.1949
Changes in cognitive functioning following treatment of late-life depression.
Meryl A. Butters,James T. Becker,Robert D. Nebes,Michelle D. Zmuda,Benoit H. Mulsant,Bruce G. Pollock,Charles F. Reynolds +6 more
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TL;DR: Elderly depressed patients with cognitive impairment may experience improvement in specific domains following antidepressant treatment but may not necessarily reach normal levels of performance, particularly in memory and executive functions.
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Abstract: OBJECTIVE: Knowledge of the relationship between various clinical characteristics and cognitive functioning is advancing, but little is known about the cognitive response to treatment for geriatric depression. The purpose of this study was to examine the cognitive response to treatment for patients with late-life depression. METHOD: Subjects included 45 nondemented, elderly depressed patients who achieved remission after 12 weeks of antidepressant treatment and 20 elderly comparison subjects. All subjects were administered a battery of clinical measures, including cognitive screening instruments, before and after treatment. RESULTS: As a group, the elderly depressed patients showed a small improvement in overall cognitive functioning after treatment. Among depressed patients with concomitant cognitive impairment at baseline, performance on the Mattis Dementia Rating Scale domains of conceptualization and initiation/perseveration improved significantly relative to those of depressed patients with normal co...
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Benoit H. Mulsant,Bruce G. Pollock,Robert D. Nebes,Mark D. Miller,John T. Little,Jackie Stack,Patricia R. Houck,Salem Bensasi,Sati Mazumdar,Charles F. Reynolds +9 more
TL;DR: Nortriptyline and paroxetine appear to have similar efficacy and tolerability in the acute treatment of older depressed patients, including hospitalized patients and those with melancholic features.
The Use of the Hamilton Rating Scale for Depression in Elderly Patients With Cognitive Impairment and Physical Illness
Benoit H. Mulsant,Robert A. Sweet,A. Hind Rifai,Rona E. Pasternak,Ann B. McEachran,George S. Zubenko +5 more
TL;DR: A prospective study to assess the impact of cognitive impairment and medical burden on the Hamilton Ratingh Scale for Depression (Ham-D) scores in older psychiatric inpatients found valid ratings of the severity of depressive symptoms in elderly patients with a broad range of Cognitive impairment and physical illness.
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Cognitive outcome following tricyclic and electroconvulsive treatment of major depression in the elderly.
Alan Stoudemire,Connie D. Hill,Robin G. Morris,David Martino-Saltzman,Holland R. Markwalter,Barbara Lewison +5 more
TL;DR: The data suggest that cognitive dysfunction associated with depression may improve after treatment in a substantial number of elderly patients, including those receiving ECT, which emphasizes the need for optimal initial and long-term antidepressant strategies for this population.
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Neuropsychological deficits among older depressed patients with predominantly psychological or vegetative symptoms
TL;DR: It is suggested that neuropsychological deficits associated with depression may be limited to those patients with primarily vegetative symptoms, and that psychological outpatients had significantly better performance than the vegetative group on several tasks.
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Neuroimaging and affective disorder in late life: a review.
TL;DR: Current evidence particularly suggests that subcortical atrophy may be an important factor in the genesis of affective disorder in old age, and the use of brain imaging techniques may have particular bearing upon identification of etiology of Affective disorder, prediction of treatment response, or risk of relapse.
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