Journal Article10.1016/0306-4522(83)90108-2
Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6).
2.3K
TL;DR: It appears that the age-related changes of memory function as well as some of the behavioral disturbances seen in the dementia of Alzheimer's Disease may be related to pathological alterations along central cholinergic pathways.
read more
About: This article is published in Neuroscience. The article was published on 01 Dec 1983. The article focuses on the topics: Basal forebrain & Cholinergic Fibers.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Cholinergic neuromodulation and Alzheimer's disease: from single cells to network simulations.
TL;DR: The chapter discusses the results that provide insight into the regulatory role of acetylcholine in learning, and recall and suggest novel mechanisms for the decline in memory function that accompanies AD.
27
Subcortical connections of the basal ganglia
TL;DR: The Basal Ganglia comprise a group of forebrain nuclei that are interconnected with the cerebral cortex, thalamus and brainstem that are involved in various functions, including motor control and learning, sensorimotor integration, reward and cognition.
27
Distributions of Choline Acetyltransferase and Acetylcholinesterase Activities in Layers of Rat Superior Colliculus
C D Ross,D A Godfrey +1 more
TL;DR: Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities were assayed in samples dissected from sagittal sections through rat superior colliculus, whose terminations may correlate in location with the distributions of the enzyme activities.
27
AMPA‐induced Lesions of the Basal Forebrain Differentially Affect Cholinergic and Non‐cholinergic Neurons: Lesion Assessment Using Quantitative In Situ Hybridization Histochemistry
TL;DR: There is a population of non‐cholinergic pallidal neurons which are insensitive to AMPA but not to ibotenic acid, reflecting a possibly heterogeneous distribution of NMDA and non‐NMDA subtypes of glutamate receptors within the rat basal forebrain.
27
Distribution of 125I-neurotensin binding sites in human forebrain: comparison with the localization of acetylcholinesterase.
TL;DR: The data suggest that neurotensin (NT) may directly influence the activity of magnocellular cholinergic neurons in the human basal forebrain, and may be involved in the physiopathology of dementing disorders such as Alzheimer's disease, in which these neurons have been shown to be affected.
27
References
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
5.6K
Brain stem reticular formation and activation of the EEG
G. Moruzzi,Horace W. Magoun +1 more
TL;DR: In this paper, it was shown that reticular activation is associated with the activation of the reticular formation of the brain stem, and that reticulus activation can be induced by low frequency stimulation of the diffuse thalamic projection system, rather than intra-cortical spread following the arrival of afferent impulses at the sensory receiving areas of the cortex.
4.2K
•Journal Article
Brain stem reticular formation and activation of the EEG. Electroencephalogr., clin.
TL;DR: The possibility is considered that a background of maintained activity within this ascending brain stem activating system may account for wakefulness, while reduction of its activity either naturally, by barbiturates, or by experimental injury and disease, may respectively precipitate normal sleep, contribute to anesthesia or produce pathological somnolence.
2.6K