Cellular Cholesterol Efflux Mediated by Cyclodextrins DEMONSTRATION OF KINETIC POOLS AND MECHANISM OF EFFLUX
Patricia G. Yancey,Wendi V. Rodrigueza,E. P. C. Kilsdonk,Genevieve W. Stoudt,William J. Johnson,Michael C. Phillips,George H. Rothblat +6 more
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TL;DR: It seems that cyclodextrin molecules are substantially more efficient than phospholipid acceptors, because cholesterol molecules desorbing from a membrane surface can diffuse directly into the hydrophobic core of a cyclodeXTrin molecule without having to desorb completely into the aqueous phase before being sequestered by the acceptor.
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About: This article is published in Journal of Biological Chemistry. The article was published on 05 Jul 1996. and is currently open access. The article focuses on the topics: Cyclodextrin & Efflux.
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Citations
Effect of cholesterol-loaded cyclodextrins on cryosurvival of dog spermatozoa.
TL;DR: It is concluded that incorporation of cholesterol in semen extender results in a beneficial increase in post-thaw semen quality in dogs.
Polyrotaxane-based systemic delivery of β-cyclodextrins for potentiating therapeutic efficacy in a mouse model of Niemann-Pick type C disease
Atsushi Tamura,Nobuhiko Yui +1 more
TL;DR: Analysis of tissue cholesterol revealed that PRX treatment markedly suppressed the tissue accumulation of cholesterol in the NPC mouse model, but did not alter cholesterol content in wild‐type mice, and acid‐labile PRX is therefore a promising candidate for potentiating the efficacy of &bgr;‐CD in the treatment of NPC disease.
Reduction of Sphingomyelin Level without Accumulation of Ceramide in Chinese Hamster Ovary Cells Affects Detergent-resistant Membrane Domains and Enhances Cellular Cholesterol Efflux to Methyl-β-cyclodextrin
TL;DR: The results suggest that the steady state level of cholesterol at the plasma membrane is little affected by the sphingomyelin levels in Chinese hamster ovary cells, but that sphingomeelin levels play an important role in the retention of cholesterol in the plasma membranes against efflux to extracellular cholesterol-acceptors, due to interaction between sphingomelin and cholesterol in detergent-resistant membrane domains.
An Impedance-Based Approach for Sensing Cyclodextrin-Mediated Modulation of Membrane Cholesterol.
TL;DR: In this article , a biomembrane-based organic electronic platform is presented to detect interactions of cell membrane constituents with methyl-β-cyclodextrin (MβCD).
Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death.
G. Kellner-Weibel,W. G. Jerome,Donald Small,G. J. Warner,J. K. Stoltenborg,M. A. Kearney,Martha H. Corjay,Michael C. Phillips,George H. Rothblat +8 more
TL;DR: Treatment with U18666A results in the sequestering of FC in a pool that prevents it from causing various responses to FC deposition in macrophages, and each of the metabolic changes elicit by the accumulation of excess FC was either diminished or eliminated.
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