Book Chapter10.1016/S0065-230X(08)60055-X
Cell-Mediated Immunity to Tumor Cells
287
TL;DR: The evidence for the existence of specific, cell-mediated immunity, both in vivo and in vitro , against tumor-associated cell surface antigens is presented and the possible role of assays in the diagnosis, prognosis, and therapy of cancer is discussed.
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Abstract: Publisher Summary An individual's immunological response to some of the antigens can result in protection against tumor growth. However, it has been found that the generation of antitumor immunity is not always effective and may at times even lead to the acceleration of tumor growth. This chapter reviews the information on the role of the immune system in limiting tumor growth and discusses the concept of immunological surveillance. It discusses the types of antigens that have been associated with tumors, their specificity, and their potential significance. It also presents the evidence for the existence of specific, cell-mediated immunity, both in vivo and in vitro , against tumor-associated cell surface antigens. There is considerable evidence for the role of immune cells in the resistance of the host to tumor growth. The chapter discusses the possible role of assays in the diagnosis, prognosis, and therapy of cancer.
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