Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
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TL;DR: The clinical relevance of celldeath, focusing on biomarkers; the contribution of cell death to drug-induced, viral, and fatty liver disease and liver cancer; and evidence for cell death pathways as therapeutic targets are reviewed.
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About: This article is published in Gastroenterology. The article was published on 01 Oct 2014. and is currently open access. The article focuses on the topics: Liver disease & Chronic liver disease.
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Osamu Takeuchi,Shizuo Akira +1 more
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TL;DR: The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.
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Role of the Calcium-Sensing Receptor in Cardiomyocyte Apoptosis via the Sarcoplasmic Reticulum and Mitochondrial Death Pathway in Cardiac Hypertrophy and Heart Failure
Fanghao Lu,Songbin Fu,Xiaoning Leng,Xinying Zhang,Shiyun Dong,Yajun Zhao,Huan Ren,Hulun Li,Xin Zhong,Changqing Xu,Weihua Zhang +10 more
TL;DR: It is demonstrated that CaR activation caused Ca2+ release from the SR into the mitochondria and induced cardiomyocyte apoptosis through the SR and mitochondrial apoptotic pathway in failing hearts.
The Danger Model: A Renewed Sense of Self
TL;DR: A model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign is outlined.