CD39 and CD73 in immunity and inflammation
1K
TL;DR: The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.
read more
About: This article is published in Trends in Molecular Medicine. The article was published on 01 Jun 2013. and is currently open access.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCR?-chain, which highlights the immunopathological aspect of the disease
Annika Åstrand,Fatma N Hamed,Marta Bertolini,Alfredo Rossi,Afsaneh Maleki-Dizaji,Andrew G. Messenger,Andrew J. G. McDonagh,Rachid Tazi-Ahnini +7 more
TL;DR: The distribution of circulating Treg subsets in AA patients with active hair loss and healthy subjects by flow cytometry suggests that these Treg clonotypes may have a protective effect and that they may be an exciting subject for future therapeutic applications.
Adenosine 2A Receptor Activation Amplifies Ibrutinib Antiplatelet Effect; Implications in Chronic Lymphocytic Leukemia
TL;DR: In this article , the authors investigated the role of adenosine generated by the microenvironment in ibrutinib-associated bleeding in chronic lymphocytic leukemia (CLL), and proposed a novel mechanism of platelet dysfunction via the adenosinergic pathway during BTK inhibitor therapy.
The Ecto-5′nucleotidase/CD73 Mediates Leishmania amazonensis Survival in Macrophages
TL;DR: Data demonstrate that L. amazonensis induces a regulatory phenotype in macrophages, which by activating the CD39/CD73 pathway allows parasite survival through the action of immunomodulatory adenosine receptors.
Vitamin D levels in patients with chronic hepatitis B
TL;DR: 1. CD73 (ecto-5’-nucleotidase) hepatocyte levels differ across mouse strains and contribute to Mallory-Denk body formation, as well as adenosine synthesis and function in regulatory T cell biology.
3
Many Faces of Regulatory T Cells: Heterogeneity or Plasticity?
TL;DR: The phenotypic diversity of regulatory T cells (Tregs) is due to heterogeneity or plasticity? The distinction between the two terms is unclear.
3
References
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
16.6K
How regulatory T cells work.
TL;DR: The hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate TReg-cell function is proposed.
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
TL;DR: In the 10 years since the previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to major changes in the recommendations, but there have been so many other developments that an update is needed.
1.3K
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
Giovanna Borsellino,Markus Kleinewietfeld,Diletta Di Mitri,Alexander Sternjak,Adamo Diamantini,Raffaella Giometto,Sabine Höpner,Diego Centonze,Giorgio Bernardi,Maria Luisa Dell'Acqua,Paolo Maria Rossini,Luca Battistini,Olaf Rötzschke,Kirsten Falk +13 more
TL;DR: In humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease and Notably, patients with the remitting/relapsing form of multiple sclerosis have strikingly reduced numbers of CD39(+) Treg cells in the blood.
1.2K