Journal Article10.1016/J.JHEP.2015.07.039
CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways.
Jibin Li,Qichao Huang,Xiaoyu Long,Jing Zhang,Xiaojun Huang,Jiye Aa,Hushan Yang,Zhi-Nan Chen,Jinliang Xing +8 more
TL;DR: It is demonstrated that CD147 is a critical regulator of fatty acid metabolism, which provides a strong line of evidence for this molecule to be used as a drug target in cancer treatment.
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About: This article is published in Journal of Hepatology. The article was published on 01 Dec 2015. The article focuses on the topics: PI3K/AKT/mTOR pathway & Fatty acid synthase.
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Citations
The metabolism of cancer cells during metastasis.
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Lipid droplets: platforms with multiple functions in cancer hallmarks.
André L S Cruz,André L S Cruz,Ester A. Barreto,Narayana P. B. Fazolini,João P. B. Viola,Patrícia T. Bozza +5 more
TL;DR: Current evidence related to the biogenesis, composition and functions of lipid dropletsrelated to the hallmarks of cancer: inflammation, cell metabolism, increased proliferation, escape from cell death, and hypoxia are discussed.
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Lipid metabolism in cancer progression and therapeutic strategies
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TL;DR: Recent evidence implicating the contribution of lipid metabolic reprogramming in cancer to cancer progression is reviewed, the molecular mechanisms underlying lipid metabolism rewiring in cancer, and potential therapeutic strategies directed toward lipid metabolism in cancer are discussed.
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Aberrant lipid metabolism as a therapeutic target in liver cancer.
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Fatty acid oxidation contributes to IL-1β secretion in M2 macrophages and promotes macrophage-mediated tumor cell migration
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