Catalytic Asymmetric Dearomatization by Transition-Metal Catalysis: A Method for Transformations of Aromatic Compounds

TL;DR: Regioselective dearomative amidoximation of nonactivated arenes enabled by photohomolytic cleavage of N‐nitrosamides affords highly regioselective spirocyclizative 1,2- or 1,4-difunctionalization.

TL;DR: Photocatalyzed aerobic dearomatization of naphthylamines under visible-light irradiation enables the selective formation of hydroxylated products through singlet oxygen generation.

TL;DR: A novel, simple, effective and rapid synthetic method to construct the C-2 trifluoromethylated indolinyl ketones via a copper-catalyzed cyclization reaction between N-alkylaniline and β-α,β-unsaturated enones was developed.

TL;DR: An unprecedented acid- and ligand-controlled divergent allylation of indoles with unactivated skipped enynes via Pd hydride catalysis has been disclosed and provides a platform for synthesizing indolenines and N-allylindoles.

TL;DR: Asymmetric catalysis, in its infancy in the 1960s, has dramatically changed the procedures of chemical synthesis, and resulted in an impressive progression to a level that technically approximates or sometimes even exceeds that of natural biological processes.

TL;DR: Asymmetric catalysis, in its infancy in the 1960s, has dramatically changed the procedures of chemical synthesis, and resulted in an impressive progression to a level that technically approximates or sometimes even exceeds that of natural biological processes as discussed by the authors.

TL;DR: This critical review discusses historical and contemporary research in the field of transition metal-catalyzed carbon-hydrogen (C-H) bond activation through the lens of stereoselectivity, placing an emphasis on reactions that are (or may soon become) relevant in the realm of organic synthesis.