Catalytic Asymmetric Dearomatization by Transition-Metal Catalysis: A Method for Transformations of Aromatic Compounds

TL;DR: By introducing a chiral PHOX ligand (L5), asymmetric dearomatization reactions of anthranils with vinylcyclopropanes proceeded with excellent enantioselectivity, likely owing to the formation of a borane-anthranil complex which has been confirmed by NMR experiments.

TL;DR: A catalytic, dearomative cycloaddition reaction with pyridines using photoinduced energy transfer catalysis is introduced, thereby advancing dearomatization methodology and increasing the topology of pyridine dearOMatization products.

TL;DR: A photocatalytic system for the dearomative hydroarylation of benzene derivatives has been developed that functions at room tempera-ture in a green solvent system without the need for precious metal-based catalysts or reagents or the generation of stoichiometric metal byproducts.

TL;DR: A novel approach on chiral phosphoric acid catalyzed Mannich-type cyclization toward the formation of diastereomerically and enantiomerically enriched pentacyclic spiroindolines has been established.

TL;DR: Asymmetric catalysis, in its infancy in the 1960s, has dramatically changed the procedures of chemical synthesis, and resulted in an impressive progression to a level that technically approximates or sometimes even exceeds that of natural biological processes.

TL;DR: Asymmetric catalysis, in its infancy in the 1960s, has dramatically changed the procedures of chemical synthesis, and resulted in an impressive progression to a level that technically approximates or sometimes even exceeds that of natural biological processes as discussed by the authors.

TL;DR: This critical review discusses historical and contemporary research in the field of transition metal-catalyzed carbon-hydrogen (C-H) bond activation through the lens of stereoselectivity, placing an emphasis on reactions that are (or may soon become) relevant in the realm of organic synthesis.