Journal Article10.3109/14017431.2015.1136079
Cardiomyocyte Ca2+ dynamics: clinical perspectives.
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TL;DR: The role of local Ca2+ homeostasis in healthy cardiac muscle cells is summarized, and how mismanaged Ca2+.
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Abstract: In the heart, Ca(2+) signals regulate a variety of biological functions ranging from contractility to gene expression, cellular hypertrophy and death. In this review, we summarize the role of local Ca(2+) homeostasis in these processes in healthy cardiac muscle cells, and highlight how mismanaged Ca(2+) handling contributes to the pathophysiology of conditions such as cardiac arrhythmia, ischemic heart disease, cardiac hypertrophy and heart failure. Aiming to provide an introduction to the field with a clinical perspective, we also indicate how current and future therapies may modulate cardiomyocytes Ca(2+) handling for the treatment of patients.
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Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery
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TL;DR: The results show that the GDF11-dependent maintenance of physical and functional communication between SR and mitochondria is critical to allow Ca2+ transfer between both organelles and energy metabolism in the cardiomyocyte and to avoid the activation of Ca2-dependent pro-hypertrophic signaling pathways.
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Cardiac voltage gated calcium channels and their regulation by β-adrenergic signaling
TL;DR: The modulation of VGCCs by &bgr;ARs in normal and pathological conditions incorporating functional and structural aspects is reviewed, emphasizing the importance of location of proteins as it relates to their function and modulation by co‐signaling molecules.
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Jiaxin Xie,Xiaoting Yan,Guoqiang Xu,Xiaolin Tian,Nisha Dong,Jing Feng,Penghui Liu,Meng Li,Yannan Zhao,Cailing Wei,Yi Lyu,Guijin Ma,Guohua Song,Tong Wang,Xiaoyan Yan +14 more
TL;DR: The results of this study are helpful for identify a potential mechanism and biomarkers of fluoride-induced myocardial contraction function damage, moreover, which can provide a new insight into the heart toxicity of fluoride in animals at the proteomics level.
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