Journal Article10.1007/S00384-012-1447-1
Carbohydrate antigen 19-9 is a valuable prognostic factor in colorectal cancer patients with normal levels of carcinoembryonic antigen and may help predict lung metastasis
Pei Ching Lin,Jen Kou Lin,Chun Chi Lin,Huann Sheng Wang,Shung Haur Yang,Jeng Kai Jiang,Yuan Tzu Lan,Tzu Chen Lin,Anna Fen Yau Li,Wei Shone Chen,Shih Ching Chang +10 more
65
TL;DR: CA19-9 may be a prognostic factor for CRC patients with normal CEA levels and an aggressive follow-up protocol for lung metastasis should be used for these patients.
read more
Abstract: We retrospectively analyzed preoperative levels of carbohydrate antigen (CA) 19-9 in colorectal cancer (CRC) patients to determine the prognostic value of CA19-9 in CRC patients with normal carcinoembryonic antigen (CEA) levels. A total of 639 patients who underwent curative surgery at Taipei Veterans General Hospital between 2002 and 2006 were enrolled. We excluded 254 patients (39.7 %) with high preoperative CEA levels and analyzed 385 patients with normal CEA levels. The measured endpoint was the postoperative disease-free survival (DFS). The prognostic value of CA19-9 was determined using log-rank test and Cox regression analysis. High CA19-9 levels were significantly associated with advanced disease and were detected in 5.8 % of patients with stage I disease, 11.7 % of those with stage II disease, and 22.5 % of those with stage III disease (P < 0.001). The 5-year DFS in patients with normal CA19-9 levels was 82.0 %, which was significantly higher than that in patients with high CA19-9 levels (68 %; P < 0.001). In a multivariate analysis, the most important independent factor affecting the 5-year DFS was tumor–node–metastasis stage (95 % CI, 1.26–2.36; HR = 1.72). After stratification by other factors, high CA19-9 level remained an independent prognostic factor for patients with normal CEA levels. Patients with high CA19-9 levels also showed a higher incidence of lung metastasis (23.1 %) than those with normal CA19-9 levels (7.2 %). CA19-9 may be a prognostic factor for CRC patients with normal CEA levels. An aggressive follow-up protocol for lung metastasis should be used for these patients.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Association between Carcinoembryonic Antigen, Carbohydrate Antigen 19-9 and Body Mass Index in Colorectal Cancer Patients
Salimullah Akand,A. Z. M. Mostaque Hossain,Mohiuddin Aslam +2 more
- 21 Jun 2020
TL;DR: To assess the relation between CEA & CA 19-9 level and body mass index in colorectal carcinoma, a Prospective Observational Study was carried out at Department of Surgery, Dhaka Medical College Hospital from January, 2016 to December, 2016.
Prognostic value of carcinoembryonic antigen (CEA) and CA 19-9 levels in patients with obstructive colorectal cancer treated with a self-expandable metallic stent and curative surgery
Ryuichiro Sato,Masaya Oikawa,Tetsuya Kakita,Tomoya Abe,Naoya Akazawa,Haruka Okano,Kei Ito,Takashi Tsuchiya +7 more
Additional file 2 of Preoperative serum CA19-9 should be routinely measured in the colorectal patients with preoperative normal serum CEA: a multicenter retrospective cohort study
Li Zhenhui,Zhu Haibin,Pang Xiao-lin,Mao Yun,Yi Xiaoping,Li Chunxia,Lei Ming,Cheng Xianshuo,Liang Lei,Wu Jiamei,Ding Yingying,Yang Jun,Sun Yingshi,Zhang Tao,You Dingyun,Liu Zaiyi +15 more
- 09 Sep 2022
Abstract: Additional file 2: Table S1.Baseline characteristics by participant site. Table S2.Multivariate analyses of recurrence-free survival in total population (Cox model). Table S3.Multivariate analyses of overall survival in total population (Cox model). Table S4.Interaction between preoperative CEA and CA19-9 with risk of outcomes. Table S5.Multivariate analyses of recurrence-free survival in colorectal cancer subgroup with CEA < 5 ng/ml (Cox model). Table S6.Multivariate analyses of recurrence-free survival in colorectal cancer subgroup with CEA ≥ 5 ng/ml (Cox model). Table S7. Multivariate analyses of overall survival in colorectal cancer subgroup with CEA < 5 ng/ml (Cox model). Table S8.Multivariate analyses of overall survival in colorectal cancer subgroup with CEA ≥ 5 ng/ml (Cox model). Table S9.A frailty model analysis of preoperative CA19-9 (cutoff: 37 U/ml) on colorectal cancer outcomes in total population. TableS10.Cox proportional hazard regression analysis of preoperative CA19-9 (cutoff:74 U/ml) on colorectal cancer outcomes in total population. Table S11.Relationship between preoperative CA19-9 and benefit from adjuvant chemotherapyin patients with stage II colorectal cancer.
Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer.
Paul Dowling,Paul Dowling,David J. Hughes,Annemarie Larkin,Justine Meiller,Michael Henry,Paula Meleady,Vincent J. Lynch,Barbara Pardini,Alessio Naccarati,Miroslav Levy,Pavel Vodicka,Paul Neary,Martin Clynes +13 more
TL;DR: The diagnosis and management of CRC could be enhanced by the discovery and validation of new candidate biomarkers, as found in this study, aimed at facilitating early detection and/or patient stratification together with providing information on the complex behaviour of cancer cells.
References
•Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
- 17 Sep 2013
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
20.9K
AJCC Cancer Staging Manual. 6th ed
FL Greene,David L. Page,ID Fleming,JV Fritz,CM Balch,DG Haller +5 more
- 01 Jan 2002
4.4K
Microsatellite instability in cancer of the proximal colon
TL;DR: Colorectal tumor DNA was examined for somatic instability at (CA)n repeats on human chromosomes 5q, 15q, 17p, and 18q, and this instability was significantly correlated with the tumor's location in the proximal colon and with increased patient survival and loss of heterozygosity.
3.3K
ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal Cancer
Gershon Y. Locker,Stanley R Hamilton,Jules Harris,John M. Jessup,Nancy E. Kemeny,John S. Macdonald,Mark R. Somerfield,Daniel F. Hayes,Robert C. Bast +8 more
TL;DR: It is recommended that carcinoembryonic antigen (CEA) be ordered preoperatively, if it would assist in staging and surgical planning, and data are insufficient to recommend the routine use of p53, ras, thymidine synthase, dihydropyrimidine dehydrogenase,Thymidine phosphorylase, microsatellite instability, 18q loss of heterozygosity, or deleted in colon cancer (DCC) protein in the management of patients with col
1.6K
Improved efficacy by individualized combination therapy with Peg IFN-a 2a and ADV in HBeAg positive chronic hepatitis B patients.
Yadong Wang,Caiyan Zhao,Wei Wang,Chuan Shen,Hong-Zhi Lu,Li Zhang,Weiyan Yu,Jun-ying Zhou,Wen-Zhao Yan +8 more
TL;DR: Individualized combination therapy can achieve higher antiviral response rates and accelerate undetectable HBV DNA and elevate HBeAg clearance/seroconversion rates to a greater degree than Peg-IFNa-2a monotherapy.
1.5K