Cannabis and psychosis
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TL;DR: The UK government is considering reclassifying cannabis because of concerns about links with mental health problems, but what does the evidence show?
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Abstract: The UK government is considering reclassifying cannabis because of concerns about links with mental health problems. What does the evidence show?
read more
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Citations
Cannabinoid CB1 receptor: Role in primate prefrontal circuitry and schizophrenia
Stephen Melford Eggan
- 20 Sep 2007
TL;DR: It is concluded that reductions in the expression of the CB1 receptor mRNA and protein in CCK neurons represent a novel neuropathological entity in the DLPFC of individuals with schizophrenia, which suggests a novel drug target for the treatment of cognitive dysfunction in schizophrenia.
2
Neurowissenschaftliche Aspekte des chronischen Cannabiskonsums
TL;DR: Aufbauende interdisziplinare Forschungsansatze konnen helfen, die Vielschichtigkeit der cannabisbezogenen Storungen and ihrer therapeutischen Relevanz besser zu verstehen.
1
References
Role of Endogenous Cannabinoids in Synaptic Signaling
TL;DR: The synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation, and the fine-grain anatomical distribution of the neuronal cannabinoid receptor CB1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release.
Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study
Louise Arseneault,Mary Cannon,Richie Poulton,Robin M. Murray,Avshalom Caspi,Terrie E. Moffitt +5 more
TL;DR: This is the first prospective longitudinal study of adolescent cannabis use as a risk factor for adult schizophreniform disorder, taking into account childhood psychotic symptoms, and the Dunedin multidisciplinary health and development study has a 96% follow up rate at age 26.
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Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction.
Avshalom Caspi,Terrie E. Moffitt,Terrie E. Moffitt,Mary Cannon,Mary Cannon,Joseph L. McClay,Robin M. Murray,HonaLee Harrington,Alan Taylor,Louise Arseneault,Ben Williams,Antony W. Braithwaite,Richie Poulton,Ian W. Craig +13 more
TL;DR: Findings provide evidence of a gene x environment interaction and suggest that a role of some susceptibility genes is to influence vulnerability to environmental pathogens.
1.4K
CANNABIS AND SCHIZOPHRENIA A Longitudinal Study of Swedish Conscripts
TL;DR: Persistence of the association after allowance for other psychiatric illness and social background indicated that cannabis is an independent risk factor for schizophrenia.
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The psychotomimetic effects of intravenous Delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis
Deepak Cyril D'Souza,Edward Perry,Lisa MacDougall,Yola Ammerman,Thomas B. Cooper,Thomas B. Cooper,Yu-te Wu,Gabriel Braley,Ralitza Gueorguieva,John H. Krystal +9 more
TL;DR: It is indicated that Δ-9-THC produces a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resemble some aspects of endogenous psychoses and warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders.
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