Cannabidiol's neuroprotective properties and potential treatment of traumatic brain injuries
TL;DR: In this paper , a review describes the cascades of damage caused by TBI and CBD's neuroprotective mechanisms to counter them and discuss important future clinical research directions for integrating CBD in treatment protocols.
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Abstract: Cannabidiol (CBD) has numerous pharmacological targets that initiate anti-inflammatory, antioxidative, and antiepileptic properties. These neuroprotective benefits have generated interest in CBD's therapeutic potential against the secondary injury cascade from traumatic brain injury (TBI). There are currently no effective broad treatment strategies for combating the damaging mechanisms that follow the primary injury and lead to lasting neurological consequences or death. However, CBD's effects on different neurotransmitter systems, the blood brain barrier, oxidative stress mechanisms, and the inflammatory response provides mechanistic support for CBD's clinical utility in TBI. This review describes the cascades of damage caused by TBI and CBD's neuroprotective mechanisms to counter them. We also present challenges in the clinical treatment of TBI and discuss important future clinical research directions for integrating CBD in treatment protocols. The mechanistic evidence provided by pre-clinical research shows great potential for CBD as a much-needed improvement in the clinical treatment of TBI. Upcoming clinical trials sponsored by major professional sport leagues are the first attempts to test the efficacy of CBD in head injury treatment protocols and highlight the need for further clinical research.
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Citations
Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review
Kuldeep Singh,Bharat Bhushan,D. Chanchal,Satish Kumar Sharma,Ketki Rani,Manoj Kumar Yadav,Prateek Kumar Porwal,Shivendra Kumar,Ashwani Sharma,Tarun Virmani,Girish Kumar Gupta and Vinod Kumar,Abdullah Al Noman +11 more
TL;DR: This investigation presents a revised viewpoint on its suitability as a therapeutic intervention for neurological illnesses, including how CBD could protect neurons, control neuroinflammation, fend off oxidative stress, and manage neuronal excitability.
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CBD enhances the cognitive score of adolescent rats prenatally exposed to THC and fine-tunes relevant effectors of hippocampal plasticity
V. Castelli,Gianluca Lavanco,Cesare D’Amico,Salvatore Feo,Giuseppe Tringali,Martin Kuchař,Carla Cannizzaro,Anna Brancato +7 more
TL;DR: The present results show that prenatal THC impairs hippocampal memory functions and the underlying synaptic plasticity; CBD is able to mitigate cognitive impairment in both reinforcement- and aversion-related tasks and the neuroadaptation of hippocampal excitatory synapses and CB1R-related signaling.
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Exosomes derived from microglia overexpressing miR- 124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury
Yan Wang,Dai Li,Lan Zhang,Zhenyu Yin,Zhaoli Han,Xintong Ge,Meimei Li,Jing Zhao,Shishuang Zhang,Yan Zuo,Xiangyang Xiong,Han Gao,Qiang Liu,Fanglian Chen,Ping Lei +14 more
TL;DR: Exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum stress and delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly reduced.
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Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway
Marjan Talebi,Mohammad-Mehdi Sadoughi,Seyed Abdulmajid Ayatollahi,Elaheh Ainy,Roghayeh Kiani,Alireza Zali,MirMohammad Miri +6 more
- 01 Dec 2023
TL;DR: This study explores the therapeutic potential of cannabidiol (CBD) and its association with the Nrf2 signaling pathway, highlighting its potential to impact the treatment and prevention of various health conditions, including cardiovascular diseases, cancers, and neurodegenerative disorders.
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Emerging roles of cannabinoid receptor CB2 receptor in the central nervous system: therapeutic target for CNS disorders
Kanchan Bala,Pratyush Porel,Khadga Raj Aran +2 more
2
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