Cancer research needs a better map.

TL;DR: Ghandi et al. as discussed by the authors used a deep learning-based pipeline to find biomarkers of drug response and gene essentiality, and showed that random downsampling to only 1,500 proteins has limited impact on predictive power, consistent with protein networks being highly connected and coregulated.

TL;DR: In this paper , the potency and efficacy of 2,025 clinically relevant two-drug combinations were evaluated, generating a dataset encompassing 125 molecularly characterized breast, colorectal and pancreatic cancer cell lines.

TL;DR: In this article, a review of the key hallmarks of cancer (e.g., autophagy, the role of redox signaling), current unmet clinical needs, the requirement for sensitive and specific biomarkers for early detection, surveillance, prognosis and drug monitoring, role of the microbiome and the goals of personalized/precision medicine are discussed.

TL;DR: In this article , the authors identify three intrinsic transcriptional subtypes of metastatic castration-resistant prostate cancer: androgen receptor (AR) pathway + prostate cancer (PC) (ARPC), mesenchymal and stem-like PC (MSPC), and neuroendocrine PC (NEPC).

TL;DR: A large-scale, prospective clinical sequencing initiative using a comprehensive assay, MSK-IMPACT, through which tumor and matched normal sequence data from a unique cohort of more than 10,000 patients with advanced cancer are compiled and identified clinically relevant somatic mutations, novel noncoding alterations, and mutational signatures that were shared by common and rare tumor types.

TL;DR: It was found that mutated cancer genes were associated with cellular response to most currently available cancer drugs, and systematic pharmacogenomic profiling in cancer cell lines provides a powerful biomarker discovery platform to guide rational cancer therapeutic strategies.

TL;DR: DEMETER, an analytical framework that segregates on- from off-target effects of RNAi, demonstrates the basis behind one such predictive model linking hypermethylation of the UBB ubiquitin gene to a dependency on UBC and provides a foundation for a cancer dependency map that facilitates the prioritization of therapeutic targets.

TL;DR: It is reported how cancer-driven alterations identified in 11,289 tumors from 29 tissues can be mapped onto 1,001 molecularly annotated human cancer cell lines and correlated with sensitivity to 265 drugs.