Cancer genome sequencing and its implications for personalized cancer vaccines.
Lijin Li,Peter S. Goedegebuure,Elaine R. Mardis,Matthew J. Ellis,Xiuli Zhang,John M. Herndon,Timothy P. Fleming,Beatriz M. Carreno,Ted H. Hansen,William E. Gillanders +9 more
TL;DR: Preliminary analyses of the epitope landscape in breast cancer suggest that individual tumors express significant numbers of novel antigens to the immune system that can be specifically targeted through cancer vaccines.
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Abstract: New DNA sequencing platforms have revolutionized human genome sequencing. The dramatic advances in genome sequencing technologies predict that the $1,000 genome will become a reality within the next few years. Applied to cancer, the availability of cancer genome sequences permits real-time decision-making with the potential to affect diagnosis, prognosis, and treatment, and has opened the door towards personalized medicine. A promising strategy is the identification of mutated tumor antigens, and the design of personalized cancer vaccines. Supporting this notion are preliminary analyses of the epitope landscape in breast cancer suggesting that individual tumors express significant numbers of novel antigens to the immune system that can be specifically targeted through cancer vaccines.
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Citations
Neoantigen vaccine: an emerging tumor immunotherapy
Miao Peng,Miao Peng,Yongzhen Mo,Yian Wang,Pan Wu,Yijie Zhang,Fang Xiong,Can Guo,Xu Wu,Xu Wu,Yong Li,Xiaoling Li,Guiyuan Li,Guiyuan Li,Wei Xiong,Wei Xiong,Zhaoyang Zeng,Zhaoyang Zeng +17 more
TL;DR: Tumor vaccines targeting neoantigens mainly include nucleic acid, dendritic cell (DC)-based, tumor cell, and synthetic long peptide (SLP) vaccines, which might achieve better therapeutic effects in the future.
Preclinical and clinical development of neoantigen vaccines
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Ugur Sahin,Sebastian Kreiter,Mustafa Diken,Jan Diekmann,Michael Koslowski,Cedrik M. Britten,John C. Castle,Martin Löwer,Bernhard Y. Renard,Tana Omokoko,Johannes Hendrikus De Graaf +10 more
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TL;DR: In this article, the authors proposed a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signatures obtained in step (a).
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Ugur Sahin,Heinrich Haas,Sebastian Kreiter,Mustafa Diken,Daniel Fritz,Martin Meng,Lena M. Kranz,Kerstin Reuter +7 more
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TL;DR: In this article, pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration are described. But they are not suitable for use in immunotherapy.
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Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation.
Lijin Li,Xiuli Zhang,Xiaoli Wang,Samuel W. Kim,John M. Herndon,Michelle Becker-Hapak,Beatriz M. Carreno,Beatriz M. Carreno,Nancy B. Myers,Mark A. Sturmoski,Michael D. McLellan,Christopher A. Miller,Tanner M. Johanns,Benjamin R. Tan,Gavin P. Dunn,Timothy P. Fleming,Timothy P. Fleming,Ted H. Hansen,S. Peter Goedegebuure,William E. Gillanders +19 more
TL;DR: In this paper, the authors developed and optimized a DNA vaccine platform to target multiple neoantigens and induce antitumor immune responses in preclinical models and neoantigen-specific responses in clinical translation.
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