Journal Article10.1038/NM1087
Cancer genes and the pathways they control.
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TL;DR: The purposes of this review are to highlight examples of progress in many areas of cancer research, indicate where knowledge is scarce and point out fertile grounds for future investigation.
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Abstract: The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.
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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
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References
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Ewan R. Cameron,James C. Neil +1 more
TL;DR: The state of progress in elucidating the oncogenic roles of the Runx genes is the subject of this review, and recent observations are drawn together in a tentative model for the effects of Runx deregulation on hematopoietic cell differentiation.
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