Canadian Laboratory Initiative on Pediatric Reference Interval Database (CALIPER): pediatric reference intervals for an integrated clinical chemistry and immunoassay analyzer, Abbott ARCHITECT ci8200.

TL;DR: The present study suggests that muscle weakness is a clinical feature of HPR, and lower muscle quality and limb deformities contribute to this functional deficit.

TL;DR: Thyroid function tests in adolescents display complex, sexually dimorphic patterns, and implementation of adolescence-specific reference ranges may be appropriate.

TL;DR: The prevalence of dyslipidemia in the German LIFE Child cohort are similar to the US-American prevalence of triglycerides, total cholesterol, LDL and HDL cholesterol as well as apolipoproteins A1 and B.

TL;DR: This review will provide a brief introduction to the current approach to establishment of reference intervals, will highlight the current gaps in data available in paediatric populations, and review a recent Canadian initiative, CALIPER (Canadian Laboratory Initiative on Paediatric Reference Intervals), to establish a comprehensive database for both traditional and emerging biomarkers of paediatric disease.

TL;DR: Data from recent blood-chemistry studies indicate that conventional normal ranges are likely to be less sensitive than desired to significant changes in an individual9s biochemical state, which supports the continued development and use of cumulative systems for reporting laboratory test results for individuals.

TL;DR: It is proposed that robust statistical analysis can be of great use for determinations of reference intervals from limited or possibly unreliable data.