Patent
Calcium receptor modulating agents
Michael G. Kelly,Shimin Xu,Ning Xi,Philip Miller,John Kincaid,Chiara Ghiron,Thomas S. Coulter +6 more
- 23 May 2003
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TL;DR: In this paper, the authors describe methods of treating diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula I. The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them.
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Abstract: The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula I.
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Citations
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TL;DR: In this paper, compounds according to Formula (I), or stereoisomer, prodrug, polymorph, or pharmaceutically acceptable salt forms thereof, wherein X, Y, R 1, R 6, R 7, and R 8 are as defined, which compounds are effective inhibitors of PI3-kinase and/or other medically and clinically relevant kinases.
64
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TL;DR: In this article, the present invention if directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and processes for preparing such compounds, and also directed to methods of treating diseases mediated by the enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
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Pyrrolidine derivative or salt thereof
Shunichiro Hachiya,Makoto Oku,Hana Mukai,Takashi Shin,Keisuke Matsuura,Ryushi Seo,Takashi Kamikubo,Yoh Terada,Masanao Sanagi,Kousei Yoshihara,Taisuke Takahashi +10 more
- 18 May 2006
TL;DR: In this paper, it was found that pyrrolidine derivatives which are characterized by the possession of aminomethyl group substituted with arylalkyl group or the like, or salts thereof have excellent CaSR agonistic regulatory activity and also have excellent selectivity with CYP2D6 inhibitory activity having a possibility of causing drug interaction.
35
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- 27 May 2005
TL;DR: Arylalkylamines represented by the general formula (I) or pharmacologically acceptable salts thereof; a process for the production of the compounds, use of compounds as activator for Ca-sensitive receptors, i.e., as CaSR agonist, and medicinal compositions containing the compounds as the active ingredient wherein Ar is aryl or heteroaryl; R1 is a group selected from the group consisting of cyclic hydrocarbon groups and heterocyclic groups; n is an integer of 1 to 3; and X is a free single bond, -CH2
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TL;DR: In this paper, a modified clot-binding compound can selectively bind to clotted plasma protein, wherein the composition causes clotting and amplifies the accumulation of the composition in tumors.
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References
•Book
Advanced Organic Chemistry: Reactions, Mechanisms, and Structure
Jerry March
- 01 Jun 1977
TL;DR: Localized Chemical bonding Delocalized Chemical Bonding Bonding Weaker than Covalent Stereochemistry Carbocations, Carbanions, Free Radicals, Carbenes and Nitrenes Mechanisms and Methods of Determining them Photochemistry Acids and Bases Effects of Structure on Reactivity Aliphatic Nucleophilic Substitution Aromatic Electrophilic Substitutes Aliphatically Electrophilic Substitution Free-Radical Substitution Addition to Carbon-Carbon Multiple Bonds Adding to Carbon Hetero Multiple Bonds Eliminations Rearrangements Ox
5.8K
Calcimimetics with potent and selective activity on the parathyroid calcium receptor.
Edward F. Nemeth,Michael E. Steffey,Lance G. Hammerland,B. C. P. Hung,B. C. Van Wagenen,E. G. Delmar,M. F. Balandrin +6 more
TL;DR: The discovery of calcimimetic compounds with potent and selective activity enables a pharmacological approach to regulating plasma levels of PTH and could conceivably provide a specific medical therapy for primary hyperparathyroidism.
605
Patent
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
Peter T. W. Cheng,Pratik Devasthale,Jeon Yoon T,Chen Sean,Hao Zhang +4 more
- 22 Feb 2002
TL;DR: In this paper, the authors defined antidiabetic agents and anti-obesity agents with the following structure (i.e., where m is 0, 1 or 2; n is 0 or 1; Q is C or N; A is (CH2)x where x is 1 to 5; X is CH or N, X 2 is C, N, O or S; X 3 is C N, N O orS; X 4 is O N, S, O N or S, X 5 and X 6 is C.
225
Patent
Calcium receptor-active molecules
Edward F. Nemeth,Bradford C. Van Wagenen,Manuel F. Balandrin,Eric G. DelMar,Scott T. Moe +4 more
- 21 Aug 1992
TL;DR: In this paper, the authors present a set of molecules which can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably if the extracellular ion is Ca 2+ and the effect is on the cell having a calcium receptor, and uses of such molecules, proteins, nucleic acids and antibodies.
173
Patent
Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them
Kenneth B. Sloan,Roy Little +1 more
- 23 Apr 1981
TL;DR: In this paper, the structural formula of known non-steroidal anti-inflammatory agents and a process for preparing them are disclosed, said prodrugs having the structural formulas having the following properties.
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