Book Chapter10.1007/978-1-4899-1775-1_7
Calcium-Activated Potassium Channels in Adrenal Chromaffin Cells
Christopher J. Lingle,C.R. Solaro,Murali Prakriya,Jiu Ping Ding +3 more
- 01 Jan 1996
- Vol. 4, pp 261-301
84
TL;DR: There are provocative differences between the two types of inactivation which require us to propose that the native inactivation domain of BKi channels may occlude access of permeant ions to the BK channel permeation pathway in a position at some distance from the actual mouth of the channel.
read more
Abstract: The rich diversity of voltage-dependent K+-selective ion channels emphasizes the central role that the K+ channel superfamily plays in defining and modifying the electrical behavior of virtually all cells that express such channels (Rudy, 1988; Covar-rubias et al., 1991). As a consequence of differences in the rates and voltage dependence of activation, deactivation, and inactivation, various K+-selective channels determine a variety of cellular electrical properties, including the rates of action potential repolarization, the duration of afterhyperpolarizations, the frequency of repetitive firing, and aspects of the resting potential. Furthermore, K+ channels appear to be important targets of biochemical cascades that modulate ion channel function, since subtle alterations in K+ channel function can markedly change the underlying electrical behavior of a cell.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels
TL;DR: The first cloned potassium channel gene was the Drosophila voltage-gated shaker channel, and this was rapidly followed by the identification of other potassium channel genes.
1K
BKCa-Cav Channel Complexes Mediate Rapid and Localized Ca2+-Activated K+ Signaling
Henrike Berkefeld,Claudia A. Sailer,Wolfgang Bildl,Volker Rohde,Jörg-Oliver Thumfart,Silke Eble,Norbert Klugbauer,Ellen Reisinger,Josef Bischofberger,Dominik Oliver,Hans-Günther Knaus,Uwe Schulte,Bernd Fakler +12 more
TL;DR: Heterologously expressed BKCa-Cav complexes reconstitute a functional “Ca2+ nanodomain” where Ca2+ influx through the Cav channel activates BK Ca in the physiological voltage range with submillisecond kinetics, enabling BkCa-mediated membrane hyperpolarization that controls neuronal firing pattern and release of hormones and transmitters in the central nervous system.
371
Presynaptic Ca2+-Activated K+ Channels in Glutamatergic Hippocampal Terminals and Their Role in Spike Repolarization and Regulation of Transmitter Release
Hua Hu,Li-Rong Shao,Sorush Chavoshy,Ning Gu,Maria Trieb,Ralf Behrens,Petter Laake,Olaf Pongs,Hans-Günther Knaus,Ole Petter Ottersen,Johan F. Storm +10 more
TL;DR: Electrophysiology and immunogold cytochemistry are combined to demonstrate the existence of functional BK channels in presynaptic terminals in the hippocampus and compare their functional roles in somata and terminals of CA3 pyramidal cells, indicating that the functional role of Bk channels depends on their subcellular localization.
350
Control of Alternative Splicing of Potassium Channels by Stress Hormones
Jiuyong Xie,David P. McCobb +1 more
TL;DR: The hormonal stress axis is likely to control the excitable properties of epinephrine-secreting cells by regulating alternative splicing of Slo messenger RNA.
312
Molecular mechanisms of BK channel activation.
TL;DR: The voltage sensor and the ligand sensor allosterically control K+ flux through the pore-gate domain in response to various stimuli, thereby linking cellular metabolism and membrane excitability.
215
References
A quantitative description of membrane current and its application to conduction and excitation in nerve
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.
Muscarinic activation of ionic currents measured by a new whole-cell recording method
Richard Horn,Alain Marty +1 more
TL;DR: Nystatin, applied extracellularly, is shown to cause a rapid and reversible increase of membrane conductance to cations, and dose-response curves for the effect of ACh on Ca-activated K currents are obtained.
Biophysical and molecular mechanisms of shaker potassium channel inactivation
TL;DR: A region near the amino terminus with an important role in inactivation has been identified and the results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation.
1.6K
Sodium and calcium channels in bovine chromaffin cells
TL;DR: Inward currents in chromaffin cells were studied with the patch‐clamp technique and current recordings were obtained in cell‐attached, outside‐out and whole‐cell recording configurations.
1K