Cadmium Toxicity and Treatment
TL;DR: Detoxification of cadmium with EDTA and other chelators is possible and has been shown to be therapeutically beneficial in humans and animals when done using established protocols.
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Abstract: Cadmium is a heavy metal of considerable toxicity with destructive impact on most organ systems. It is widely distributed in humans, the chief sources of contamination being cigarette smoke, welding, and contaminated food and beverages. Toxic impacts are discussed and appear to be proportional to body burden of cadmium. Detoxification of cadmium with EDTA and other chelators is possible and has been shown to be therapeutically beneficial in humans and animals when done using established protocols.
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Citations
Strain and sex effects on blood accumulation of lead, chromium, and cadmium in strains from the Collaborative Cross mouse population
Brittni Ming-Whitfield,Danila Cuomo,David W. Threadgill,David W. Threadgill +3 more
- 28 Oct 2025
Abstract: Abstract Lead (Pb), chromium (Cr), and cadmium (Cd) are heavy metals that contaminate sites throughout North America. Historically, toxicological effects of Pb, Cr, or Cd compounds have been investigated in a hybrid mouse strain, B6C3F1. However, humans have more genetic diversity and population variability in response to toxicants than is represented in this homogeneous mouse model, which leaves genetic effects on dose response uncertain. Use of the Collaborative Cross (CC) addresses the problem of limited genetic diversity inherent in models like B6C3F1. In previous work, blood Pb levels in panel of female CC lines exposed to high-dose (0.1%) lead acetate showed a strain dependent response. Four strains from the original study with varying Pb blood levels after exposure were selected to determine if strain and sex dependence was exhibited in a two-week acute exposure to Pb, but also to Cr or Cd exposure. To investigate genetic background influence on metal deposition, five animals of each sex from each strain were placed on an American diet for one week prior to dosing high- (0.1%) or low- (0.01%) dose Pb acetate, high- (0.1%) or low- (0.01%) sodium dichromate, or high- (0.1%) or low- (0.01%) cadmium chloride via drinking water ad libitum for 14-days, matching the standard short-term exposure of the National Toxicology Program. Body composition was measured before the start of dosing and prior to necropsy using EcoMRI. Blood Pb at necropsy from this study suggests the strain dependent trends observed in previous exposures is conserved for acute Pb exposure but with different trends for Cr and Cd indicating that even a small panel of strains will not suffice for estimating variation across all toxicants.
Immunochemical Evaluation of Biomarkers of Carcinogenesis, Angiogenesis, Neuro-Cancer Interactions and Demyelination in Cadmium Chloride-Induced Testicular Toxicity in Rats.
Adelaja Akinlolu,Mubarak Ameen,Gabriel Ebito,Nnaemeka Tobechukwu Asogwa,Raheem Akindele,Bamidele Fagbohunka +5 more
TL;DR: CdCl 2 -induced testicular toxicity, angiogenesis and neurocancer interaction are ameliorated by post-treatments with MO11 and MS06.
N-acetylcysteine dual and antagonistic effect on cadmium cytotoxicity in human leukemia cells.
TL;DR: Surprisingly, it is observed that addition of low concentrations of NAC can drastically potentiate cadmium cytotoxicity solely via ROS production, but all adverse effects of the metal were prevented by NAC at high concentrations.
Distribution of remaining Cd in MSWI fly ash washed with nitric acid
TL;DR: In this paper, the change of different factions of Cd in treated (i.e., washed with nitric acid) MSWI fly ash was investigated. And the results indicated that fractions of CD have changed significantly after nitric acids washing procedures, which resulted in a higher potential risk (or higher bioavailability index) for living creatures.
Water resources pollution associated with risks of heavy metals from Vatukoula Goldmine region, Fiji.
Satendra Kumar,Abu Reza Md. Towfiqul Islam,H.M. Touhidul Islam,Hasanuzzaman,Victor Ongoma,Rahat Khan,Javed Mallick +6 more
TL;DR: In this article, a multidisciplinary approach was developed to characterize the contamination level, source apportionment, co-existence, and degree of ecological and human health risks of HMs on water resources in the Vatukoula Goldmine region (VGR), Fiji.
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Cadmium stress: an oxidative challenge
Ann Cuypers,Michelle Plusquin,Tony Remans,Marijke Jozefczak,Els Keunen,Heidi Gielen,Kelly Opdenakker,Ambily Ravindran Nair,Elke Munters,Tom Artois,Tim S. Nawrot,Jaco Vangronsveld,Kelly Smeets +12 more
TL;DR: The current review gives an overview on Cd-induced ROS production and anti-oxidative defense in organisms under different Cd regimes and the C d-induced oxidative challenge is discussed with a focus on damage and signaling as downstream responses.
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