Cadmium-induced decrease in RUNX2 mRNA expression and recovery by the antioxidant N-acetylcysteine (NAC) in the human osteoblast-like cell line, Saos-2.
Spenser S. Smith,Jackeline Rodriguez Reyes,Kate S. Arbon,Wendy A. Harvey,Lindsey M. Hunt,Sara J. Heggland +5 more
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TL;DR: It is hypothesized that cadmium exposure induces oxidative stress which leads to decreased RUNX2 mRNA expression and increased apoptotic death, and predicted that the antioxidant NAC mitigates the damaging effects of cadmiam.
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About: This article is published in Toxicology in Vitro. The article was published on 01 Feb 2009. and is currently open access. The article focuses on the topics: Cadmium chloride & Oxidative stress.
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Citations
Cellular mechanisms of cadmium-induced toxicity: a review.
TL;DR: Current evidence suggests that exposure to Cadmium induces genomic instability through complex and multifactorial mechanisms, most important seems to be cadmium interaction with DNA repair mechanism, generation of reactive oxygen species and induction of apoptosis.
641
Cadmium-Induced Pathologies: Where Is the Oxidative Balance Lost (or Not)?
TL;DR: The Cd-induced oxidant/antioxidant status as well as the damage versus signalling scenario in relation to Cd toxicity are highlighted, including a section on cell proliferation and carcinogenesis.
Toxicity of cadmium in musculoskeletal diseases.
D. Reyes-Hinojosa,Carlos Alberto Lozada-Pérez,Y. Zamudio Cuevas,Alberto López-Reyes,Gabriela Angélica Martínez-Nava,Javier Fernández-Torres,Anell Olivos-Meza,Carlos Landa-Solís,María Concepción Gutiérrez-Ruiz,E. Rojas del Castillo,Karina Martínez-Flores +10 more
TL;DR: Knowing the negative impact of Cd toxicity at the articular level can help understand the damage mechanisms it produces, leading to the development of musculoskeletal diseases.
137
Cadmium toxicity: A role in bone cell function and teeth development.
TL;DR: In this article, the authors explored the molecular mechanisms of Cadmium-induced bone injury starting from bone cell function and teeth development, and provided new directions for removing this heavy metal from the environment.
116
Cadmium, follicle-stimulating hormone, and effects on bone in women age 42-60 years, NHANES III.
TL;DR: Long-term cadmium exposure at environmental levels is associated with increased serum FSH, and both FSH and UCd are associated with bone loss, in US women aged 42-60 years.
95
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