Journal Article10.1016/0163-7258(91)90014-D
Ca2+ extrusion across plasma membrane and Ca2+ uptake by intracellular stores.
Ludwig Missiaen,Frank Wuytack,Luc Raeymaekers,Humbert De Smed,Guy Droogmans,I Declerck,Rik Casteels +6 more
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TL;DR: The aim of this review is to summarize the various systems that remove Ca2+ from the cytoplasm by summarizing the functional regulation of these systems and the recent progress obtained with molecular-biology techniques, which pointed to the existence of different isoforms of the Ca 2+ pump.
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About: This article is published in Pharmacology & Therapeutics. The article was published on 01 Jan 1991.
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Citations
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease
Anavaj Sakuntabhai,Victor L. Ruiz-Perez,S. Carter,N. Jacobsen,Susan Burge,Sarah Monk,Martin D. Smith,Colin S. Munro,Michael Conlon O'Donovan,Nicholas John Craddock,Raju Kucherlapati,Jonathan L. Rees,Michael John Owen,G M Lathrop,Anthony P. Monaco,Tom Strachan,Alain Hovnanian +16 more
TL;DR: It is demonstrated that mutations in ATP2A2 cause Darier disease and disclose a role for this pump in a Ca2+-signalling pathway regulating cell-to-cell adhesion and differentiation of the epidermis.
741
Gentamicin and bone morphogenic protein-2 (BMP-2)-delivering heparinized-titanium implant with enhanced antibacterial activity and osteointegration.
TL;DR: Dual drug (antibiotics and osteoinductive protein)-eluting Ti substrates such as GS/BMP-2/Hep-Ti are a promising material for the enhanced osteointegration and implant longevity in orthopedics and dentistry.
168
Structure and function of inositol triphosphate receptors
Colin W. Taylor,Alan Richardson +1 more
TL;DR: The ligand recognition characteristics of Ins(1,4,5) P 3 receptors and their functional properties in their native environment and after purification are discussed, and these properties are related to what is known of the structure of the receptor.
155
Cellular Uptake of Lead Is Activated by Depletion of Intracellular Calcium Stores
TL;DR: In conclusion, Pb2+ crosses the plasma membrane of GH3, C6, and HEK293 cells via channels that are activated by profound depletion of intracellular Ca2+ stores.
139
The plasma membrane calcium pump--a physiological perspective on its regulation.
TL;DR: This review focuses on the physiological role of the plasma membrane Ca(2+)+ Mg(2+)-dependent adenosine triphosphatase (PM Ca( 2+)-ATPase) in cellular signalling and recent work investigating the possible regulation of the PM Ca2+ pump by G proteins and agonists.
135
References
2,5-Di-(tert-butyl)-1,4-benzohydroquinone mobilizes inositol 1,4,5-trisphosphate-sensitive and -insensitive Ca2+ stores.
K A Oldershaw,Colin W. Taylor +1 more
TL;DR: It is concluded that the Ins(1,4,5) P 3‐sensitive stores arc a subset of those sensitive to tBuBHQ and that the latter is therefore unlikely to prove useful as a tool to discriminateinsensitive Ca2+ stores though it may provide opportunities to design more selective agents.
45
Thyroid hormone differentially affects mRNA levels of Ca-ATPase isozymes of sarcoplasmic reticulum in fast and slow skeletal muscle.
TL;DR: Levels for the type I and type II isoforms of sarcoplasmic reticulum (SR) Ca‐ATPase were determined in soleus and extensor digitorum longus muscle of euthyroid, hypothyroid, and hyperthyroid rats.
44
Characterization of the hormone-sensitive Ca2+ uptake activity of the hepatic endoplasmic reticulum
TL;DR: The effects of glucagon and insulin on the kinetics of hepatic microsomal Ca2+ uptake were investigated and the effect of these hormones on the activity of Ca2-stimulated ATPase was also studied.
44
Inhibition of Na-Ca exchange by general anesthetics.
TL;DR: It is suggested that octanol inhibits like sodium, and the synergism stems from the cooperativity of sodium inhibition at the binding and regulatory sites of the exchanger, which could contribute to their negative inotropic effect.
43
Ruthenium red and compound 48/80 inhibit the smooth-muscle plasma-membrane Ca2+ pump via interaction with associated polyphosphoinositides.
Ludwig Missiaen,Humbert De Smedt,Guillaume Droogmans,Frank Wuytack,Luc Raeymaekers,Rik Casteels +5 more
TL;DR: Although ruthenium red and compound 48/80 affect the ATPase differently, both substances most likely inhibit the smooth-muscle plasma-membrane Ca2+ pumping by counteracting the stimulation by negatively charged phospholipids.
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