Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo
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TL;DR: DiLillo et al. as mentioned in this paper showed that anti-stalk mAbs can mediate antibody-dependent cell cytotoxicity and require interactions with Fc receptors for their in vivo neutralizing activity.
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Abstract: Monoclonal antibodies (mAbs) that bind the stalk domain of the influenza hemagglutinin glycoprotein have been shown to have broadly neutralizing activity against diverse influenza subtypes. In this study, DiLillo et al. report that, unlike strain-specific anti–hemagglutinin head domain mAbs, anti-stalk mAbs can mediate antibody-dependent cell cytotoxicity and require interactions with Fc receptors for their in vivo neutralizing activity.
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Citations
Combined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection.
Li-Meng Yan,Olive T. W. Li,Chek M. Poh,Ranawaka A.P.M. Perera,Sophie A. Valkenburg,Malik Peiris,Leo L.M. Poon +6 more
TL;DR: A panel of sequential 4-dose immunization regimens tested the synergistic effect of combining different vaccine platforms to enhance heterosubtypic protection against influenza viruses and found the combined use of inactivated and live-attenuated vaccines could achieve the best heterological protection.
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Broadly Neutralizing Antibodies to Highly Antigenically Variable Viruses as Templates for Vaccine Design.
TL;DR: Development of vaccines to highly variable viruses such as Human Immunodeficiency Virus and influenza A viruses faces multiple challenges and reverse vaccinology approaches to generate universal vaccines against both pathogens are described and compared.
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Towards a Universal Influenza Virus Vaccine Eliciting Broadly Neutralising Haemagglutinin Antibodies
TL;DR: Adjuvant enhanced vaccination strategies to elicit potent bnAb and improved B cell memory responses will have an immense impact in global health care and pre-pandemic preparation.
Fc-mediated functions and the treatment of severe respiratory viral infections with passive immunotherapy – a balancing act
Hillary A. Vanderven,Stephen J. Kent +1 more
TL;DR: Overall, it is postulate that treating respiratory viral infections with hIVIG represents a delicate balance between protection and immunopathology.
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Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial
Carolyn M. Boudreau,John F. Burke,Kiel Shuey,Caitlin R Wolf,Joanne Katz,James M. Tielsch,Subarna K. Khatry,Steven C. LeClerq,Janet A. Englund,Helen Y. Chu,Galit Alter +10 more
TL;DR: In this article , the transfer of functional antibodies and defined humoral factors contributing to immunity against influenza in a clinical trial of maternal influenza vaccination were comprehensively profiled in the mothers during pregnancy and at birth.
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