Journal Article10.1016/J.TCB.2008.08.007
Breaching the basement membrane: who, when and how?
R. Grant Rowe,Stephen J. Weiss +1 more
466
TL;DR: New data indicate that protease-dependent transmigration is largely reliant on a group of membrane-anchored metalloenzymes, termed the membrane-type matrix metalloproteinases, which irreversibly remodel BM structure.
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About: This article is published in Trends in Cell Biology. The article was published on 01 Nov 2008.
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Citations
Rethinking NM23: An extracellular role for NDPKinase in breast cancer
Iain L. O. Buxton,Senny Nordmeier +1 more
TL;DR: This study reevaluates the role of Nm23/NDPKinase in breast cancer, suggesting its extracellular function in maintaining extracellular purines may be crucial in understanding cancer spread and dormancy, potentially leading to new therapeutic approaches.
The protective effect of low-dose minocycline on brain microvascular ultrastructure in a rodent model of subarachnoid hemorrhage
Daria Gendosz de Carrillo,Sebastian Student,Daniel Bula,Łukasz Mielańczyk,Malgorzata Burek,Patrick Meybohm,Halina Jędrzejowska-Szypułka +6 more
TL;DR: In this article , the beneficial effects of low-dose neuroprotective agent minocycline (1 mg/kg) on brain microvascular ultrastructures have been studied in detail.
The intestine: A highly dynamic microenvironment for IgA plasma cells
TL;DR: In this article , the spatial interplay of the intestinal epithelium with plasma cells and its potential contribution to IgA plasma cell generation, homing, and longevity is discussed, and the impact of nutritional AhR ligands on intestinal epithelial cell-IgA plasma cells interaction is described.
A shift from papillary to reticular fibroblasts enables tumour-stroma interaction and invasion
TL;DR: The results show that Pfs contain cancer cells more within the epidermis than Rfs, which is clearly predisposed to differentiate into CAFs upon SCC signals, assisting invasion and EMT.
Integrin Acts Upstream of Netrin Signaling to Regulate Formation of the Anchor Cell's Invasive Membrane in C. elegans
TL;DR: A role for integrin is revealed in regulating the plasma membrane targeting and netrin-dependent orientation of a specialized invasive membrane domain in C. elegans.
References
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Tissue Destruction by Neutrophils
TL;DR: With increasing frequency, the human neutrophil is being implicated as a mediator of tissue-destructive events in inflammatory diseases ranging from rheumatoid arthritis and myocardial reperfusion injury to respiratory distress syndromes, blistering skin disorders, and ulcerative colitis.
4.4K
Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
4.4K
Tumour-cell invasion and migration: diversity and escape mechanisms
Peter Friedl,Katarina Wolf +1 more
TL;DR: Cancer cells possess a broad spectrum of migration and invasion mechanisms and learning more about the cellular and molecular basis of these different migration/invasion programmes will help to understand how cancer cells disseminate and lead to new treatment strategies.
3.4K
Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
TL;DR: The identification of Snail, ZEB and some basic helix-loop-helix factors as inducers of epithelial–mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
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