Journal Article10.1016/J.TCB.2008.08.007
Breaching the basement membrane: who, when and how?
R. Grant Rowe,Stephen J. Weiss +1 more
466
TL;DR: New data indicate that protease-dependent transmigration is largely reliant on a group of membrane-anchored metalloenzymes, termed the membrane-type matrix metalloproteinases, which irreversibly remodel BM structure.
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About: This article is published in Trends in Cell Biology. The article was published on 01 Nov 2008.
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Citations
Advances in biofabrication techniques for collagen-based 3D in vitro culture models for breast cancer research
TL;DR: In this article, the authors highlight the current application of collagen-based scaffolds as 3D in vitro culture models for breast cancer research, specifically for adherence-based composite scaffolds (i.e., matrix-assisted).
MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane
Angela R.M. Kurz,Monika Pruenster,Ina Rohwedder,Mahalakshmi Ramadass,Kerstin Schäfer,Ute Harrison,Gabriel Gouveia,Claudia Nussbaum,Roland Immler,Johannes R. Wiessner,Andreas Margraf,Dae-Sik Lim,Barbara Walzog,Steffen Dietzel,Markus Moser,Christoph Klein,Dietmar Vestweber,Rainer Haas,Sergio D. Catz,Markus Sperandio +19 more
TL;DR: It is shown that MST1 is a critical regulator of neutrophil extravasation during inflammation and associates with the Rab27 effector protein synaptotagmin-like protein 1 (JFC1, encoded by Sytl1 in mice), but not Munc13-4, thereby regulating the trafficking of Rab27-positive vesicles to the cellular membrane.
ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK
Sergey Filippov,Stephen L. Pinkosky,Richard J Lister,Catherine Pawloski,Jeffrey C. Hanselman,Clay T. Cramer,Rai Ajit K. Srivastava,Timothy R. Hurley,Cheryl D. Bradshaw,Mark A. Spahr,Roger S. Newton +10 more
TL;DR: ETC-1002 may provide further clinical benefits for patients with cardiometabolic risk factors by reducing systemic inflammation linked to insulin resistance and vascular complications of metabolic syndrome by activating AMPK and exerts its anti-inflammatory effects via an LKB1-dependent mechanism.
Basement membrane components are key players in specialized extracellular matrices.
Jenny Kruegel,Nicolai Miosge +1 more
TL;DR: The latest research on these unique sECM and their components with a special emphasis on embryonic and adult stem cells and their niches is reviewed, opening the possibility that such matrices can fulfill distinct functions.
Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans
Shinji Ihara,Elliott J. Hagedorn,Meghan A. Morrissey,Qiuyi Chi,Fumio Motegi,James M. Kramer,David R. Sherwood +6 more
TL;DR: Using landmark photobleaching and optical highlighting of laminin and type IV collagen, it is found that a new mechanism, basement membrane sliding, underlies basement membrane gap enlargement during uterine–vulval attachment in Caenorhabditis elegans.
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