Journal Article10.1016/J.TCB.2008.08.007
Breaching the basement membrane: who, when and how?
R. Grant Rowe,Stephen J. Weiss +1 more
466
TL;DR: New data indicate that protease-dependent transmigration is largely reliant on a group of membrane-anchored metalloenzymes, termed the membrane-type matrix metalloproteinases, which irreversibly remodel BM structure.
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About: This article is published in Trends in Cell Biology. The article was published on 01 Nov 2008.
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Citations
Gels for Live Analysis of Compartmentalized Environments (GLAnCE): A tissue model to probe tumour phenotypes at tumour-stroma interfaces.
Elisa D'Arcangelo,Nila C. Wu,Tianhao Chen,Andi Shahaj,Jose L. Cadavid,Linwen Huang,Laurie Ailles,Alison P. McGuigan +7 more
TL;DR: It was found that CAF presence resulted in the establishment of an invasion-permissive, interface-specific matrix environment, that leads to carcinoma cell movement outwards from the tumour edge and tumour cell invasion.
13
Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling
Shelly Th McClatchey,Zheng Wang,Lara M. Linden,Eric Hastie,Lin Wang,Lin Wang,Wanqing Shen,Wanqing Shen,Alan Chen,Qiuyi Chi,David R. Sherwood +10 more
TL;DR: A new morphogenetic signaling pathway is revealed that controls BM sliding to remodel tissues and restricts BM adhesion receptor DGN-1 (dystroglycan) trafficking to the cell-BM interface, which promotes BM sliding.
13
Lnc-NA inhibits proliferation and metastasis in endometrioid endometrial carcinoma through regulation of NR4A1
Linying Sun,Rongfang Zhou,Jing Dong,Shuang Liu,Yulian Jiao,Laicheng Wang,Shengnan Hu,Pengjuan He,Xiaowen Liu,Xingbo Zhao,Guosheng Jiang,Yueran Zhao +11 more
TL;DR: The results demonstrate that the Lnc‐NA‐NR4A1 axis could be a useful tumour suppressor and a promising therapeutic target for EEC.
12
Extracellular Matrix Regulation of Vascular Morphogenesis, Maturation, and Stabilization.
George E. Davis,Scott S. Kemp +1 more
TL;DR: Mechanistic details underlying the role of the extracellular matrix in controlling different steps of vascular morphogenesis and the identification of specific growth factor combinations and peptides that are required to form stabilized capillary networks are presented.
12
Correlation between hypoxia and HGF/c-MET expression in the management of pancreatic cancer.
Rishav Sharma,Rishabha Malviya +1 more
- 01 Feb 2023
TL;DR: The role of hypoxia and HGF/c-MET expression in the treatment of pancreatic cancer is discussed in this paper . But, the authors do not consider the effect of the MET gene on pancreatic malignancy.
12
References
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Tissue Destruction by Neutrophils
TL;DR: With increasing frequency, the human neutrophil is being implicated as a mediator of tissue-destructive events in inflammatory diseases ranging from rheumatoid arthritis and myocardial reperfusion injury to respiratory distress syndromes, blistering skin disorders, and ulcerative colitis.
4.4K
Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
4.4K
Tumour-cell invasion and migration: diversity and escape mechanisms
Peter Friedl,Katarina Wolf +1 more
TL;DR: Cancer cells possess a broad spectrum of migration and invasion mechanisms and learning more about the cellular and molecular basis of these different migration/invasion programmes will help to understand how cancer cells disseminate and lead to new treatment strategies.
3.4K
Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
TL;DR: The identification of Snail, ZEB and some basic helix-loop-helix factors as inducers of epithelial–mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
3.2K