Journal Article10.1159/000135625
Brain alterations in autoimmune and pharmacological models of diabetes mellitus: focus on hypothalamic-pituitary-adrenocortical axis disturbances
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TL;DR: A manifest hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis is described in two different experimental mouse models of T1D including the pharmacological one induced by streptozotocin and the spontaneous NOD (nonobese diabetic mice).
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Abstract: Type 1 diabetes (T1D) is linked to an ‘encephalopathy’ explained by some features common to the aging process, degenerative and functional disorders of the central nervous system. In the present study
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Citations
•Journal Article
Insulin dependent diabetes mellitus as an autoimmune disease.
TL;DR: Several lines of evidence support the concept that insulin dependent diabetes (IDDM) is an autoimmune disease, and the reported association of cell-surface proteins named histocompatibility antigens (HLA) with this particular disease is examined.
316
Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline.
TL;DR: Fundamental past and ongoing research on diabetes-associated cognitive decline is summarized, highlighting potential contributors, mechanistic mediators, and new pharmacological approaches to prevent and/or delay this complication.
146
Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes
Karen A. Nunley,Caterina Rosano,Christopher M. Ryan,J. Richard Jennings,Howard J. Aizenstein,Janice C. Zgibor,Tina Costacou,Robert M. Boudreau,Rachel L. Miller,Trevor J. Orchard,Judith Saxton +10 more
TL;DR: Clinically relevant cognitive impairment is highly prevalent among middle-aged adults with childhood-onset type 1 diabetes, and chronic hyperglycemia and prevalent microvascular disease were associated with cognitive impairment, relationships shown previously in younger populations with T1D.
Oxytocin-secreting system: A major part of the neuroendocrine center regulating immunologic activity
TL;DR: The fact that oxytocin may have significant effects in the body, beyond its classical functions in lactation and parturition is highlighted, and therapeutic potentials of oxytocIn in treating immunologic disorders are explored.
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Hippocampal neurovascular and hypothalamic-pituitary-adrenal axis alterations in spontaneously type 2 diabetic GK rats.
Juan Beauquis,Françoise Homo-Delarche,M.H. Giroix,Jan A. Ehses,Josiane Coulaud,Paulina Roig,Bernard Portha,Alejandro F. De Nicola,Alejandro F. De Nicola,Flavia Saravia,Flavia Saravia +10 more
TL;DR: Be Beauquis et al. as mentioned in this paper presented the Consejo Nacional de Investigaciones Cientificas y Tecnicas (CICTE) and the National Institute of Biologia y Medicina Experimental (IME) of Argentina.
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References
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TL;DR: A review of the evidence indicating hyperactivation of the HPA axis in patients with diabetes using the streptozotocin-diabetic rat as a model of type-1 diabetes and elucidating some of the mechanisms underlying HPA dysregulation in diabetes finds a better understanding of these mechanisms may be important in developing new treatment modalities for patients with Diabetes mellitus.
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Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism
Lynnetta Watts,Vara Prasad Manchem,Thomas A. Leedom,Amber L. Rivard,Robert Mckay,Dingjiu Bao,Teri Neroladakis,Brett P. Monia,Diane M. Bodenmiller,Julia Xiao-Chun Cao,Hong Yan Zhang,Amy L. Cox,Steven Jacobs,M. Dodson Michael,Kyle W. Sloop,Sanjay Bhanot +15 more
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Increased astrocyte reactivity in the hippocampus of murine models of type 1 diabetes: the nonobese diabetic (NOD) and streptozotocin-treated mice
Flavia Saravia,Flavia Saravia,Yanina Revsin,Maria Claudia Gonzalez Deniselle,Maria Claudia Gonzalez Deniselle,Susana L. González,Susana L. González,Paulina Roig,Analia Lima,Françoise Homo-Delarche,Alejandro F. De Nicola,Alejandro F. De Nicola +11 more
TL;DR: Astrocyte changes present in genetic and pharmacological models of T1D appear to reflect an adaptive process to alterations of glucose homeostasis.
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Studies of hormone action in the hippocampal formation: Possible relevance to depression and diabetes
TL;DR: The hippocampus is a brain structure involved in episodic, declarative, contextual and spatial learning and memory as well as its being a component in the control of autonomic and vegetative functions such as ACTH secretion, and its possible role in the regulation of glucose homeostasis.
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Immune response gene expression increases in the aging murine hippocampus
Akira Terao,A. Apte-Deshpande,Linda Dousman,Stephen R. Morairty,Barrett P Eynon,Thomas S. Kilduff,Yvonne R. Freund +6 more
TL;DR: Age-related increases in inflammatory potential in the brain may contribute to neurodegenerative diseases of the aged, and these findings are in contrast to a decrease in the peripheral immune response, documented by decreased T cell proliferation and decreased ratios of naive to memory T cells.
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