Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands
Chao Shi,Ting Jia,Simón Méndez-Ferrer,Tobias M. Hohl,Natalya V. Serbina,Lauren Lipuma,Ingrid Leiner,Ming O. Li,Paul S. Frenette,Paul S. Frenette,Eric G. Pamer +10 more
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TL;DR: It is demonstrated that low concentrations of Toll-like receptor (TLR) ligands in the bloodstream drive CCR2-dependent emigration of monocytes from bone marrow and that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses.
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About: This article is published in Immunity. The article was published on 22 Apr 2011. and is currently open access. The article focuses on the topics: Bone marrow & CCL23.
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