Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands
Chao Shi,Ting Jia,Simón Méndez-Ferrer,Tobias M. Hohl,Natalya V. Serbina,Lauren Lipuma,Ingrid Leiner,Ming O. Li,Paul S. Frenette,Paul S. Frenette,Eric G. Pamer +10 more
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TL;DR: It is demonstrated that low concentrations of Toll-like receptor (TLR) ligands in the bloodstream drive CCR2-dependent emigration of monocytes from bone marrow and that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses.
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About: This article is published in Immunity. The article was published on 22 Apr 2011. and is currently open access. The article focuses on the topics: Bone marrow & CCL23.
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Citations
Rationale for the potential use of mesenchymal stromal cells in liver transplantation
Morgan Vandermeulen,Céline Gregoire,Alexandra Briquet,Chantal Lechanteur,Yves Beguin,Olivier Detry +5 more
TL;DR: The use of mesenchymal stromal cells (MSCs) in solid organ transplantation has been extensively studied as discussed by the authors, and the first available clinical data seem to show that MSCs are safe to use, at least in the medium-term, but more time is needed to evaluate the potential adverse effects of long-term use.
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Aging of Bone Marrow Mesenchymal Stromal Cells: Hematopoiesis Disturbances and Potential Role in the Development of Hematologic Cancers.
Fulvio Massaro,Florent Corrillon,Basile Stamatopoulos,Nathalie Meuleman,Laurence Lagneaux,Dominique Bron +5 more
TL;DR: In this article, the authors present the main features of mesenchymal stromal cell senescence in bone marrow and their implications in hematologic cancer progression, showing that the aging of MSCs has a direct impact on their behavior and on hematopoiesis.
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Attenuation of experimental asthma by mycobacterial protein combined with CpG requires a TLR9-dependent IFN-γ-CCR2 signalling circuit.
Rafael de Queiroz Prado,Thaís Barboza Bertolini,Annie R. Piñeros,Ana Flávia Gembre,Simone G. Ramos,Célio Lopes Silva,Marcos C. Borges,Vânia Luiza Deperon Bonato +7 more
TL;DR: The potentials of Mycobacterium leprae 65‐kD heat‐shock protein or Toll‐like receptor 9 ligand (CpG oligodeoxynucleotides) as immune modulators for the treatment of airway allergic disease have been studied individually.
21
Role of Gut Inflammation in Altering the Monocyte Compartment and Its Osteoclastogenic Potential in HLA-B27-Transgenic Rats.
TL;DR: To investigate the relationship between intestinal inflammation and the central and peripheral innate immune system in the pathogenesis of HLA–B27–associated spondyloarthritis using an HLA-B27-transgenic (B27‐Tg) rat model, a novel rat model is developed.
Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism.
Kit Ming Lee,Gillian J. Wilson,Marieke Pingen,Ayumi Fukuoka,Christopher A.H. Hansell,Robin Bartolini,Laura Medina-Ruiz,Gerard J. Graham +7 more
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