Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands
Chao Shi,Ting Jia,Simón Méndez-Ferrer,Tobias M. Hohl,Natalya V. Serbina,Lauren Lipuma,Ingrid Leiner,Ming O. Li,Paul S. Frenette,Paul S. Frenette,Eric G. Pamer +10 more
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TL;DR: It is demonstrated that low concentrations of Toll-like receptor (TLR) ligands in the bloodstream drive CCR2-dependent emigration of monocytes from bone marrow and that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses.
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About: This article is published in Immunity. The article was published on 22 Apr 2011. and is currently open access. The article focuses on the topics: Bone marrow & CCL23.
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Citations
F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner
Kanae Yumimoto,Sayuri Akiyoshi,Hiroki Ueo,Yasuaki Sagara,Ichiro Onoyama,Hiroaki Ueo,Shinji Ohno,Masaki Mori,Koshi Mimori,Keiichi I. Nakayama +9 more
TL;DR: It is suggested that FBXW7 antagonizes cancer development in not only a cell-aut autonomous manner, but also a non-cell-autonomous manner, and that modulation of the FBxW7/NOTCH/CCL2 axis may provide a potential approach to suppression of cancer metastasis.
Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis.
TL;DR: It is proposed that NOD1 signaling in MSCs serves as an important pathway underlying the requirement for microbiota in the maintenance of steady-state hematopoiesis, distinct from that triggered by lipopolysaccharide in both its broad effects on multiple progenitors and specific targeting of M SCs as cytokine producing intermediates.
122
A commensal bacterial product elicits and modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammation.
Yan Wang,Sakhina Begum-Haque,Kiel Telesford,Javier Ochoa-Repáraz,Marc Christy,Eli J. Kasper,Dennis L. Kasper,Simon C. Robson,Lloyd H. Kasper +8 more
TL;DR: It is demonstrated that immune-modulatory commensal bacterial products impact the migratory patterns of CD4 Treg during CNS autoimmunity via the regulation of CD39, and these observations provide clues as to how intestinal Commensal microbiome is able to modulate Treg functions and impact host immunity in the distal site.
120
Macrophages and Cardiovascular Health
TL;DR: Signals that regulate macrophages supply and function, imaging applications that can detect changes in cell numbers and phenotype, and opportunities to modulate cardiovascular inflammation by targeting macrophage biology are highlighted.
Bone marrow niches for hematopoietic stem cells and immune cells.
TL;DR: This work reviews candidate niches for HSCs in the bone marrow controlling hematopoiesis and chronic inflammation and suggests that primitive mesenchymal cells, including CXCL12-abundant reticular (CAR) cells and Nestin-expressing cells, which have the ability to differentiate into adipocytes as well as osteoblasts act as niches.
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