Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands
Chao Shi,Ting Jia,Simón Méndez-Ferrer,Tobias M. Hohl,Natalya V. Serbina,Lauren Lipuma,Ingrid Leiner,Ming O. Li,Paul S. Frenette,Paul S. Frenette,Eric G. Pamer +10 more
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TL;DR: It is demonstrated that low concentrations of Toll-like receptor (TLR) ligands in the bloodstream drive CCR2-dependent emigration of monocytes from bone marrow and that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses.
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About: This article is published in Immunity. The article was published on 22 Apr 2011. and is currently open access. The article focuses on the topics: Bone marrow & CCL23.
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Citations
Bone Marrow Mesenchymal Stem Cells: Fat On and Blast Off by FGF21
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LNGFR+THY-1+ human pluripotent stem cell-derived neural crest-like cells have the potential to develop into mesenchymal stem cells
Takehito Ouchi,Satoru Morikawa,Shinsuke Shibata,Kimiko Fukuda,Hironobu Okuno,Takumi Fujimura,Tatsuo Kuroda,Manabu Ohyama,Wado Akamatsu,Taneaki Nakagawa,Hideyuki Okano +10 more
TL;DR: Results suggest that LNGFR+THY-1+ cells identified following NCLC induction from ESCs/iPSCs shared similar potentials with multipotent MSCs, and traced their potential for survival, migration and differentiation in the host environment.
<scp>CCR2</scp> is expressed by tendon resident macrophage and T cells, while <scp>CCR2</scp> deficiency impairs tendon healing via blunted involvement of tendon‐resident and circulating monocytes/macrophages
TL;DR: In this paper , the authors examined the tendon healing phenotype in Chemokine Receptor 2 (CCR2) reporter and knockout mice and found that CCR2GFP+ cells were present in the tendon during adult homeostasis, and single-cell RNA sequencing identified these cells as tendon resident macrophages and T cells.
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