Body Composition, Cardiometabolic Risk Factors and Comorbidities in Psoriasis and the Effect of HLA-C*06:02 Status: The HUNT Study, Norway
Å. Solvin,Vera Vik Bjarkø,Laurent F. Thomas,Kristian Hveem,Marit Saunes,Bjørn Olav Åsvold,Mari Løset +6 more
TL;DR: Altered body composition in psoriasis with increased levels of fat, and particularly metabolically active visceral fat, is pointed to and support for a broad clinical approach to psoriatic patients in a general population is provided.
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Abstract: Psoriasis has been associated with increased adiposity measures driving systemic inflammation, which may lead to metabolic dysfunction and comorbidities. In this population-based, cross-sectional study, we used data from 56 042 individuals in the fourth wave of the Trondelag Health Study (HUNT4), to investigate the associations between psoriasis and body composition measures assessed using bioelectrical impedance analysis, cardiometabolic risk factors, and comorbidities. Further, we investigated the associations between HLA-C*06:02 status, a potential clinical biomarker for a distinct psoriasis endotype, and these outcomes. Psoriasis was associated with increased adiposity measures, including increased body and visceral fat, and lower levels of skeletal muscle and soft lean mass, as well as higher prevalences of cardiovascular, respiratory and endocrine disorders. HLA-C*06:02 -positive individuals with psoriasis had lower levels of hsCRP, increased prevalence of atrial fibrillation and decreased prevalence of migraine. Our results point to altered body composition in psoriasis with increased levels of fat, and particularly metabolically active visceral fat, and provide support for a broad clinical approach to psoriatic patients in a general population.
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References
Cohort Profile: The HUNT Study, Norway
Steinar Krokstad,Arnulf Langhammer,Kristian Hveem,Turid Lingaas Holmen,Kristian Midthjell,TR Stene,Grete Helen Bratberg,Jon Heggland,Jostein Holmen +8 more
TL;DR: The HUNT Study includes large total population-based cohorts from the 1980ies, covering 125 000 Norwegian participants; HUNT1 (1984-86), HUNT2 (1995-97) and HUNT3 (2006-08), which contribute to important knowledge regarding health related lifestyle, prevalence and incidence of somatic and mental illness and disease, health determinants, and associations between disease phenotypes and genotypes.
Psoriasis of early and late onset: Characterization of two types of psoriasis vulgaris
Tilo Henseler,Enno Christophers +1 more
TL;DR: Nonpustular psoriasis shows two distinct forms, one of which is hereditary, with early onset, and the other is sporadic and occurs in older age, which shows a strong tendency to become generalized.
996
Psoriasis and comorbid diseases: Epidemiology.
Junko Takeshita,Sungat K. Grewal,Sinead Langan,Nehal N. Mehta,Alexis Ogdie,Abby S. Van Voorhees,Joel M. Gelfand +6 more
TL;DR: A rapidly expanding body of literature in various populations and settings supports additional associations between psoriasis and cardiometabolic diseases, gastrointestinal diseases, kidney disease, malignancy, infection, and mood disorders.
902
National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study
Rosa Parisi,I.Y.K. Iskandar,Evangelos Kontopantelis,Matthias Augustin,Christopher E.M. Griffiths,Christopher E.M. Griffiths,Darren M. Ashcroft +6 more
TL;DR: The estimates provided can help guide countries and the international community when making public health decisions on the appropriate management of psoriasis and assessing its natural history over time.
808
Psoriasis and Major Adverse Cardiovascular Events: A Systematic Review and Meta-Analysis of Observational Studies
TL;DR: Mild and severe psoriasis are associated with an increased risk of myocardial infarction and stroke, and future studies should include more complete covariate adjustment and characterization of Psoriasis severity.
421