Journal Article10.1242/DEV.129.10.2459
BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors
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TL;DR: Evidence strongly suggests that BMPs are the key regulators of dorsal cell identity in the spinal neural tube.
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Abstract: In the spinal neural tube, populations of neuronal precursors that express a unique combination of transcription factors give rise to specific classes of neurons at precise locations along the dorsoventral axis. Understanding the patterning mechanisms that generate restricted gene expression along the dorsoventral axis is therefore crucial to understanding the creation of diverse neural cell types. Bone morphogenetic proteins (BMPs) and other transforming growth factor beta (TGFbeta) proteins are expressed by the dorsal-most cells of the neural tube (the roofplate) and surrounding tissues, and evidence indicates that they play a role in assigning cell identity. We have manipulated the level of BMP signaling in the chicken neural tube to show that BMPs provide patterning information to both dorsal and intermediate cells. BMP regulation of the expression boundaries of the homeobox proteins Pax6, Dbx2 and Msx1 generates precursor populations with distinct developmental potentials. Within the resulting populations, thresholds of BMP act to set expression domain boundaries of developmental regulators of the homeobox and basic helix-loop-helix (bHLH) families, ultimately leading to the generation of a diversity of differentiated neural cell types. This evidence strongly suggests that BMPs are the key regulators of dorsal cell identity in the spinal neural tube.
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Citations
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Studies of the hindbrain roof plate organiser in the chick embryo
Emma Ruth Broom
- 01 Jan 2012
TL;DR: Unless another licence is stated on the immediately following page this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence.
Getting in touch with your senses: Mechanisms specifying sensory interneurons in the dorsal spinal cord.
Sandeep Gupta,Samantha J. Butler +1 more
- 25 Feb 2021
TL;DR: The molecular events that specify dorsal neuronal patterning in the spinal cord, thereby generating diverse dI identities are discussed and how this molecular understanding has led to the development of robust stem cell methods to derive multiple spinal cell types, including the dIs, are discussed.
The Bone Morphogenetic Protein Type Ib Receptor is a Major Mediator of Glial Differentiation and Cell Survival in Adult Hippocampal Progenitor Cell Culture
Anke Brederlau,Roland Faigle,Muna Elmi,A. Zarebski,A. Zarebski,Sara Sjöberg,M. Fujii,Kohei Miyazono,Keiko Funa +8 more
TL;DR: It is concluded that endogenous BMPs mediate cell survival, astroglial differentiation and the suppression of oligodendrocytic cell fate mainly via the Alk6 receptor in AHP culture.
The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter.
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