Blood sample collection in small laboratory animals
968
TL;DR: The approved blood collection techniques for laboratory animals like rodents, lagomorphs and nonrodents, as well as various regulatory agencies and guidelines, are dealt with.
read more
Abstract: Collection of blood from small laboratory animals is necessary for a wide range of scientific research and there are a number of efficient methods available for that. It is important that blood sample collection from experimental animals should be least stressful because stress will affect the outcome of the study. Various regulatory agencies and guidelines have restricted the use of animals and the techniques used for blood collection in laboratory animals. This article deals with the approved blood collection techniques for laboratory animals like rodents, lagomorphs and nonrodents. Permission of the Institute Animal Ethics Committee has been obtained for the use of animals for demonstrating the techniques.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Oxytocin Mitigates the Negative Consequences of Chronic Social Isolation in Prairie Voles (Microtus ochrogaster)
Elyse Kathleen McMahon
- 01 Jan 2017
TL;DR: It is found that six weeks of chronic isolation lead to increased CORT levels, oxidative damage, telomere degradation and anhedonia, however, daily oxytocin injections in isolated individuals prevented these negative consequences as compared to those who were isolated with and without daily vehicle injections.
Can rutin ameliorate aluminum phosphide-induced acute cardiac toxicity in adult albino rats?
Sahar M. Abo El Wafa,Heba A. El Noury +1 more
- 23 Jan 2020
TL;DR: Investigation of the possible protective effect of rutin against AlP induced cardiotoxicity in rats concluded that AlP intoxication caused ECG, biochemical and histopathological changes which were potentially improved with rutIn, which showed a significant decrease in heart rate and ST segment elevation and a significant decreases in activity of TNF-α and IL-6.
Biological Sample Collection from Experimental Animals
TL;DR: In this paper , the authors discussed the blood, urine and saliva collection methods from laboratory animals and discussed the prior permission required from the animal ethics committee for collection of biological samples from the animals.
3
Role of channels in the oxygen permeability of red blood cells
Pan Zhao,R. Ryan Geyer,Ahlam I. Salameh,Amanda B. Wass,Sara Taki,Dale Huffman,Howard J. Meyerson,Gerolf Gros,Rossana Occhipinti,Fraser J. Moss,Walter F. Boron +10 more
TL;DR: It is reported that most O2 traverses membrane-protein channels, and the first two O2 channels are identified and pointed to the existence of other O2 channel(s), all of which could be subject to physiological regulation and pharmacological intervention.
3
Purification and in vivo stability and half-life of recombinant lipid modified staphylokinase.
TL;DR: The studies confirmed the role of lipid modification as a crucial factor in confirming in vivo stability of LMSAK and proves to be beneficial in therapeutic usage.
3
References
•Book
Drug discovery and evaluation : pharmacological assays
H. Gerhard Vogel
- 15 Jan 1997
TL;DR: Thoroughly revised and expanded to two volumes, this successful reference offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs.
1.6K
Methods of Blood Collection in the Mouse
Janet Hoff
- 01 Jan 2000
TL;DR: Blood collection is used for a wide variety of scientific studies, and there are a number of efficient methods available, but it is important to remember that blood collection, because it can stress the animals, may have an impact on the outcome of research data.
Saphenous vein puncture for blood sampling of the mouse, rat, hamster, gerbil, guineapig, ferret and mink
TL;DR: A humane and practical alternative to cardiac and retro-orbital puncture, in species where venepuncture has traditionally been regarded as problematic, is described for blood collection from the lateral saphenous vein.
274
Chronic vascular catheterization in the rat: comparison of three techniques.
TL;DR: It is concluded that for long-term sampling of blood in the rat, the femoral artery catheterization procedure is preferable in terms of patency and postsurgical weight loss.
50