Blood sample collection in small laboratory animals
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TL;DR: The approved blood collection techniques for laboratory animals like rodents, lagomorphs and nonrodents, as well as various regulatory agencies and guidelines, are dealt with.
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Abstract: Collection of blood from small laboratory animals is necessary for a wide range of scientific research and there are a number of efficient methods available for that. It is important that blood sample collection from experimental animals should be least stressful because stress will affect the outcome of the study. Various regulatory agencies and guidelines have restricted the use of animals and the techniques used for blood collection in laboratory animals. This article deals with the approved blood collection techniques for laboratory animals like rodents, lagomorphs and nonrodents. Permission of the Institute Animal Ethics Committee has been obtained for the use of animals for demonstrating the techniques.
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References
•Book
Drug discovery and evaluation : pharmacological assays
H. Gerhard Vogel
- 15 Jan 1997
TL;DR: Thoroughly revised and expanded to two volumes, this successful reference offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs.
1.6K
Methods of Blood Collection in the Mouse
Janet Hoff
- 01 Jan 2000
TL;DR: Blood collection is used for a wide variety of scientific studies, and there are a number of efficient methods available, but it is important to remember that blood collection, because it can stress the animals, may have an impact on the outcome of research data.
Saphenous vein puncture for blood sampling of the mouse, rat, hamster, gerbil, guineapig, ferret and mink
TL;DR: A humane and practical alternative to cardiac and retro-orbital puncture, in species where venepuncture has traditionally been regarded as problematic, is described for blood collection from the lateral saphenous vein.
274
Chronic vascular catheterization in the rat: comparison of three techniques.
TL;DR: It is concluded that for long-term sampling of blood in the rat, the femoral artery catheterization procedure is preferable in terms of patency and postsurgical weight loss.
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