Blood — Principles and Practice of Hematology

TL;DR: The most effective management of G6PD deficiency is to prevent haemolysis by avoiding oxidative stress, and Screening programmes for the disorder are undertaken, depending on the prevalence of G 6PD deficiency in a particular community.

TL;DR: The zebrafish is firmly established as a genetic model for the study of vertebrate blood development and its blood-forming system is characterized to provide a cellular context in which to study the genetics of hematopoiesis.

TL;DR: The mechanical deformation characteristics of living cells are known to influence strongly their chemical and biological functions and the onset, progression and consequences of a number of human diseases and potential applications of the optical tweezers method are highlighted.

TL;DR: Results suggest that clinical laboratories and sites responsible for point-of-care testing of gHb need to be aware of the interferences produced in assays by genetic variants and chemically modified derivatives, and should make available alternative, non-Hb-based methods for assessing long-term glycemic control in individuals with HbCC, HbSS, or HbSC disease.

TL;DR: Results suggest that clinical laboratories and sites responsible for point-of-care testing of gHb need to be aware of the interferences produced in assays by genetic variants and chemically modified derivatives, and should make available alternative, non-Hb-based methods for assessing long-term glycemic control in individuals with HbCC, HbSS, or HbSC disease.

TL;DR: New dynamic in vitro assays that explore various hereditary blood disorders and parasitic infectious diseases that cause disruption of RBC morphology and mechanics are highlighted.

TL;DR: Polycythemia vera is a clonal disorder arising in a multipotent hematopoietic progenitor cell that causes the accumulation of morphologically normal red cells, white cells, platelets, and their progenitors in the absence of a definable stimulus.

TL;DR: It is proposed that platelets are thermosensors, primed at peripheral sites where most injuries occurred throughout evolution, and GPIb modification might permit cold platelet storage.