Open AccessBook
Biotransformations in Organic Chemistry
Kurt Faber
- 01 Jan 1992
TL;DR: This professional referencebook on Biotransformations in organic Chemistry is aimed at graduate students in Organic Chemistry and Biotechnology, scientists and professionals who want to use the powerful synthetic tool of enzymes for modern preparative organic chemistry.
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Abstract: The use of biocatalysts as enzymes and/or whole cells, offers a remarkable arsenal of highly selective transformations in preparative organic chemistry. A large number of synthetically useful reactions can be catalysed by enzymes in a highly selective manner. This book pinpoints the chemo-, regio- and stereoselective transformations which have been shown to be most useful as an alternative to the already existing methods for stereoselective synthesis. The types of reaction covered inter alia are: hydrolysis-condensation, redox-reactions, addition-elimination, carbon-carbon bond formation, halogenation, etc. Special techniques, such as enzyme-immobilization and the use of biocatalysts in organic solvents are introduced to the newcomer. This is the first approach to provide a condensed introduction into this field written from the viewpoint of an organic chemist. This professional referencebook on Biotransformations in Organic Chemistry is aimed at graduate students in Organic Chemistry and Biotechnology, scientists and professionals who want to use the powerful synthetic tool of enzymes for modern preparative organic chemistry.
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Citations
Characterization and application of xylene monooxygenase for multistep biocatalysis.
TL;DR: The results indicate that, depending on the reaction conditions, product formation could be directed to one specific product.
110
(S)‐Selective Kinetic Resolution and Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols
TL;DR: The kinetic resolution (KR) process was optimized with respect to activation of the protease and to the acyl donor, and proved to be compatible with a range of functionalized sec-alcohols, giving good to high enantiomeric ratio values.
108
A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene
Katarina Cankar,Adèle van Houwelingen,Dirk Bosch,Theo Sonke,Harro J. Bouwmeester,Jules Beekwilder +5 more
TL;DR: Surprisingly, the chicory P450 has a different regio‐specificity on (+)‐valencene compared to germacrene A and amorpha‐4,11‐diene.
107
Copper- and vanadium-catalyzed asymmetric oxidations
TL;DR: In this paper, two asymmetric metal-catalyzed oxidations are discussed, and they are used in enantioselective sulfide oxidations with hydrogen peroxide, giving optically active lactones in up to 95% ee.
107
Modulation of lipase properties in macro-aqueous systems by controlled enzyme immobilization: enantioselective hydrolysis of a chiral ester by immobilized Pseudomonas lipase.
Gloria Fernández-Lorente,Marco Terreni,Cesar Mateo,Agatha Bastida,Roberto Fernandez-Lafuente,Pere Dalmases,Joan Huguet,Jose M. Guisan +7 more
TL;DR: The catalytic behavior of the different PFL derivatives in the hydrolytic resolution of fully soluble (R,S) 2-hydroxy 4-phenyl butanoic acid ethyl ester in aqueous medium was analyzed and the enantioselectivity of the PFL-immobilized enzyme was significantly improved.
107
References
•Book
Biocatalysis in Organic Media
L.E.S. Brink,Johannes Tramper,K. Ch. A. M. Luyben,K. van 't Riet +3 more
- 01 Jun 1987
TL;DR: The epoxidation of alkenes in water/solvent two-phase systems is discussed to give an example of the scope of biotechnological processes that is obtained by using organic media.
596
Enzymes in organic synthesis-29 : Preparations of enantiomerically pure cis -2,3- and 2,4-dimethyl lactones via horse liver alcohol dehydrogenase-catalyzed oxidations☆☆☆
TL;DR: In this paper, the broad applicability of horse liver alcohol dehydrogenase-catalyzed oxidations of meso-diols as a route to chiral lactones of asymmetric synthetic value is described.
325
Biocatalysis in agricultural biotechnology
John R. Whitaker,Philip E. Sonnet +1 more
- 01 Jan 1989
TL;DR: That's it, a book to wait for in this month for releasing this book biocatalysis in agricultural biotechnology; you may not be able to get in some stress, so don't go around and seek fro the book until you really get it.
185
•Book
Biocatalysis: From Discovery to Application
Wolf-Dieter Fessner
- 15 Mar 2000
TL;DR: The present work focused on the development of biocatalytic Approaches for the Synthesis of Enantiopure Epoxides with a focus on the components of the E. coli Oligosaccharides.
155